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FLASH GENE
Symbol PHF5A contributors: - updated : 07-03-2005
HGNC name PHD finger protein 5A
HGNC id 18000
Location 22q13.3      Physical location : 41.855.721 - 41.864.708
Synonym symbol(s) INI, MGC1346, SF3b14b
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391333 22 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) GPR24 22q13.3 G protein-coupled receptor 24 SLC25A17 22q13.2 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 ST13 22q13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) LOC63929 22q13.31-q13.33 hypothetical protein LOC63929 DNAJB7 22q13.2 DnaJ (Hsp40) homolog, subfamily B, member 7 RBX1 22q13.1 ring-box 1 RPS9P2 22q13.2 ribosomal protein S9 pseudogene 2 LOC391334 22 similar to mutant beta-actin (beta-actin) EP300 22q13.2 E1A binding protein p300 LOC391335 22 similar to KIAA0563 protein L3MBTL2 22q13.31-q13.33 l(3)mbt-like 2 (Drosophila) RANGAP1 22q13.1 Ran GTPase activating protein 1 RoXaN 22q13.2 ubiquitous tetratricopeptide containing protein RoXaN TEF 22q13.1 thyrotrophic embryonic factor TOB2 22q13.2 transducer of ERBB2, 2 PHF5A 22q13.3 PHD finger protein 5A ACO2 22q13.1 aconitase 2, mitochondrial RPC8 22q13.2 RNA polymerase III subunit RPC8 PIPPIN 22q13.2-q13.31 RNA-binding protein pippin PMM1 22q13.2 phosphomannomutase 1 D15Wsu75e 22q13.2 DNA segment, Chr 15, Wayne State University 75, expressed G22P1 22q13.1 thyroid autoantigen 70kDa (Ku antigen) NHP2L1 22q13.2-q13.1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) FLJ23584 22q13.2 hypothetical protein FLJ23584 HMG17L2 22q13.2 high-mobility group (nonhistone chromosomal) protein 17-like 2 MGC40042 22q13.2 hypothetical protein MGC40042 FLJ22349 22q13.2 hypothetical protein FLJ22349 SREBF2 22q13.2 sterol regulatory element binding transcription factor 2 TNFRSF13C 22q13.1-q13.31 tumor necrosis factor receptor superfamily, member 13C C22orf18 22q13.2-q13.31 chromosome 22 open reading frame 18 SEPT3 22q13.2 septin 3 MGC26816 22q13.31 hypothetical protein MGC26816 NAGA 22q13.2 N-acetylgalactosaminidase, alpha- LOC150368 22q13.31 hypothetical protein LOC150368 LOC91689 22q13.31 hypothetical gene supported by AL449243 NDUFA6 22q13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa LOC246785 22q13.2 PTD004 pseudogene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PHD-finger-like domain that is flanked by highly basic N- and C-termini
HOMOLOGY
Homologene
FAMILY PHD-finger superfamily
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • maybe acting as a chromatin associated protein
  • small nuclear protein that enhances the response of the connexin 43 gene to estrogen
  • playing a role in the cellular response to estrogen affecting both AF-1 and AF-2 activities of the estrogen receptor alpha
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by estrogen in the myometrium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS