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FLASH GENE
Symbol PHF2 contributors: mct - updated : 10-10-2017
HGNC name PHD finger protein 2
HGNC id 8920
Location 9q22.31      Physical location : 96.338.908 - 96.441.867
Synonym name jumonji C domain-containing histone demethylase 1E
Synonym symbol(s) PHD, GRC5, KIAA0662, JHDM1E, MGC176680, KDM7C
DNA
TYPE functioning gene
STRUCTURE 102.96 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12 ANKRD19 9q22.32 ankyrin repeat domain 19 BA526D8.4 9q22.32 KRAB box containing C2H2 type zinc finger bA526D8.4 LOC389773 9 LOC389773 LOC340518 9q22.32 similar to Alox15 protein FGD3 9q22 FGD1 family, member 3 MGC26847 LOC389774 9 LOC389774 MGC11115 9q22.32 hypothetical protein MGC11115 LOC389775 9 LOC389775 NINJ1 9q22.3 ninjurin 1 PRKWNK2 9q22.3 protein kinase, lysine deficient 2 C9orf10OS 9q22.32 chromosome 9 open reading frame 10 opposite strand C9orf10 9q22.31 chromosome 9 open reading frame 10 PHF2 9q22.31 PHD finger protein 2 BARX1 9q12 BarH-like homeobox 1 PTP9Q22 9q22.32 protein tyrosine phosphatase PTP9Q22 HCP24 9q22.32 cytochrome c, somatic pseudogene ZNF169 9q22.31 zinc finger protein 169 DKFZp434I1117 9q22.32 hypothetical protein DKFZp434I1117 FLJ14753 9q22.32 hypothetical protein FLJ14753 FBP2 9q22.3 fructose-1,6-bisphosphatase 2 FBP1 9q22.3 fructose-1,6-bisphosphatase 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 splicing 5349 - 1096 - 1999 10051327
- splicing 5238 - 1101 - 1999 10051327
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PHD (C4-H-C3) zinc finger domain
  • eight nuclear localization signals (NLS)
  • two PEST and a hydrophobic domain
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb group PcG
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JHDM1D subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator affecting gene expression by influencing chromatin structure
  • co-activator function having important functional roles in neuronal development
  • PHF2, PHF8, possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus
  • repressive role for PHF2 in transcription by RNA polymerase I and II
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PHF2-ARID5B complex is a signal-sensing modulator of histone methylation and gene transcription, in which phosphorylation of PHF2 enables subsequent formation of a competent and specific histone demethylase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and induce demethylation of methylated ARID5B
  • PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of rDNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS