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FLASH GENE
Symbol PHF2 contributors: mct - updated : 10-10-2017
HGNC name PHD finger protein 2
HGNC id 8920
Location 9q22.31      Physical location : 96.338.908 - 96.441.867
Synonym name jumonji C domain-containing histone demethylase 1E
Synonym symbol(s) PHD, GRC5, KIAA0662, JHDM1E, MGC176680, KDM7C
DNA
TYPE functioning gene
STRUCTURE 102.96 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 splicing 5349 - 1096 - 1999 10051327
- splicing 5238 - 1101 - 1999 10051327
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PHD (C4-H-C3) zinc finger domain
  • eight nuclear localization signals (NLS)
  • two PEST and a hydrophobic domain
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb group PcG
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JHDM1D subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator affecting gene expression by influencing chromatin structure
  • co-activator function having important functional roles in neuronal development
  • PHF2, PHF8, possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus
  • repressive role for PHF2 in transcription by RNA polymerase I and II
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PHF2-ARID5B complex is a signal-sensing modulator of histone methylation and gene transcription, in which phosphorylation of PHF2 enables subsequent formation of a competent and specific histone demethylase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and induce demethylation of methylated ARID5B
  • PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of rDNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS