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FLASH GENE
Symbol PHF19 contributors: mct - updated : 21-09-2013
HGNC name PHD finger protein 19
HGNC id 24566
Location 9q33.2      Physical location : 123.617.930 - 123.639.606
Synonym symbol(s) PCL3, MGC23929, RP11-27I1.1, MGC131698, MGC149712, MGC149713, MTF2L1
DNA
TYPE functioning gene
STRUCTURE 21.68 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
DBC1 9q32-q33 deleted in bladder cancer 1 CDK5RAP2 9q33.3 CDK5 regulatory subunit associated protein 2 LOC389788 9 similar to EGFL5 LOC392387 9 similar to Ahcy protein FBXW2 9q34 F-box and WD-40 domain protein 2 PSMD5 9q33.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 PHF19 9q34.11 PHD finger protein 19 TRAF1 9q33-q34 TNF receptor-associated factor 1 C5 9q33 complement component 5 CEP1 9q33 centrosomal protein 1 RAB14 9q32-q34.11 RAB14, member RAS oncogene family LOC392388 9 similar to vacuolar H+-ATPase B subunit GSN 9q33.3 gelsolin (amyloidosis, Finnish type) MOST2 9q34.11 MOST2 protein STOM 9q34.1 stomatin a1/3GTP 9q34.11 alpha-1,3-galactosyltransferase pseudogene DAB2IP 9q33.1-q33.3 DAB2 interacting protein LOC158135 9q34.11 similar to H23L24.3.p NDUFA8 9q32.4-q34.41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa FLJ46909 9q34.11 FLJ46909 protein LHX6 9q34.11 LIM homeobox 6 MGC2734 MRRF 9q33-q34.1 mitochondrial ribosome recycling factor PTGS1 9q32-q33.3 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) LOC347168 9q34.11 similar to Olfactory receptor 1J1 OR1J5 9q34.11 olfactory receptor, family 1, subfamily J, member 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 4287 65.4 580 - 2011 21143197
  • PCL3L, containing an N-terminal TUDOR domain and two PHDs (plant homeodomains)
  • 5 - 1001 22.3 207 - 2011 21143197
  • differing in the 3' UTR and coding region compared to variant 1
  • the resulting isoform b is shorter and has a distinct C-terminus compared to isoform a
  • smaller isoform, PCL3S, lacking the second PHD finger (PHD2)
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Tudor domains that selectively bind to histone H3K36me3
  • two PHD-type zinc fingers, and specific PHD2 domain, which is better conserved than PHD1 in the PCL family, is also involved in the EZH2 interaction and implicated in the self-association of PCL3L
  • the first PHD domains do not exhibit histone H3K4 binding ability, nor do they affect the Tudor domain binding to histones
  • HOMOLOGY
    interspecies homolog to murine 3321402G02Rik
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in DNA-dependent regulation of transcription
  • common function of PHF1, MTF2 and PHF19 is recruitment of the PRC2 complex to its target genes for histone methylation, Hox gene silencing and ESC (Extra Sex Combs) self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • both PCL3 isoforms are physically associated with EZH2, but in different complexes
  • EHMT2 orchestrates PHF19 and KDM7A to promote histone H3K27 methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS