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FLASH GENE
Symbol PHF19 contributors: mct - updated : 21-09-2013
HGNC name PHD finger protein 19
HGNC id 24566
Location 9q33.2      Physical location : 123.617.930 - 123.639.606
Synonym symbol(s) PCL3, MGC23929, RP11-27I1.1, MGC131698, MGC149712, MGC149713, MTF2L1
DNA
TYPE functioning gene
STRUCTURE 21.68 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 4287 65.4 580 - 2011 21143197
  • PCL3L, containing an N-terminal TUDOR domain and two PHDs (plant homeodomains)
  • 5 - 1001 22.3 207 - 2011 21143197
  • differing in the 3' UTR and coding region compared to variant 1
  • the resulting isoform b is shorter and has a distinct C-terminus compared to isoform a
  • smaller isoform, PCL3S, lacking the second PHD finger (PHD2)
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Tudor domains that selectively bind to histone H3K36me3
  • two PHD-type zinc fingers, and specific PHD2 domain, which is better conserved than PHD1 in the PCL family, is also involved in the EZH2 interaction and implicated in the self-association of PCL3L
  • the first PHD domains do not exhibit histone H3K4 binding ability, nor do they affect the Tudor domain binding to histones
  • HOMOLOGY
    interspecies homolog to murine 3321402G02Rik
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in DNA-dependent regulation of transcription
  • common function of PHF1, MTF2 and PHF19 is recruitment of the PRC2 complex to its target genes for histone methylation, Hox gene silencing and ESC (Extra Sex Combs) self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • both PCL3 isoforms are physically associated with EZH2, but in different complexes
  • EHMT2 orchestrates PHF19 and KDM7A to promote histone H3K27 methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS