basic FUNCTION
| involved in the epigenetic regulation of developmental genes |
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promoting nonhomologous end-joining processes |
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involved in genome maintenance processes |
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is essential in epigenetic regulation and genome maintenance |
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can mediate deposition of the repressive H3K27me3 mark and acts as a cofactor in early DNA-damage response |
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involved in the response to DNA double-strand breaks in human cells, promotes nonhomologous end-joining processes through interaction with XRCC6/XRCC5 |
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common function of PHF1, MTF2 and PHF19 is recruitment of the PRC2 complex to its target genes for histone methylation, Hox gene silencing and ESC (Extra Sex Combs) self-renewal |