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FLASH GENE
Symbol PHC3 contributors: mct/npt - updated : 09-03-2009
HGNC name polyhomeotic homolog 3 (Drosophila)
HGNC id 15682
Location 3q26.2      Physical location : 169.805.367 - 169.899.537
Synonym name
  • early development regulator 3
  • polyhomeotic like 3
  • Synonym symbol(s) EDR3, FLJ12967, FLJ12729, HPH3, DKFZp313K1221, FLJ12729, MGC88144, PH3
    DNA
    TYPE functioning gene
    STRUCTURE 94.17 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 12687 107.3 995 - Tonkin (2002)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAM (sterile alpha motif) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • polycomb gene family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text E2F6 showed nuclear colocalization in a punctate pattern that resembled the binding of polycomb bodies to heterochromatin (Deshpande 2007)
    basic FUNCTION
  • nuclear proteins that are constituents of evolutionarily conserved protein complexes designated class II PcG complexes (Isono 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the human polycomb complex PRC-H (Deshpande 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with both PRC-H complex components and with the transcription factor E2F6 (Deshpande 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in primary osteosarcoma tumors ( loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0)(Deshpande 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS