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FLASH GENE
Symbol PHC3 contributors: mct/npt - updated : 09-03-2009
HGNC name polyhomeotic homolog 3 (Drosophila)
HGNC id 15682
Location 3q26.2      Physical location : 169.805.367 - 169.899.537
Synonym name
  • early development regulator 3
  • polyhomeotic like 3
  • Synonym symbol(s) EDR3, FLJ12967, FLJ12729, HPH3, DKFZp313K1221, FLJ12729, MGC88144, PH3
    DNA
    TYPE functioning gene
    STRUCTURE 94.17 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC253820 3q26.2-q26.31 similar to MEGF6 LOC93556 3q26.31 hypothetical protein BC011266 EVI1 3q26 ecotropic viral integration site 1 MDS1 3q21-q26 myelodysplasia syndrome 1 LOC389175 3 similar to ribosomal protein L22 LOC285262 3q26.31 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat TERC 3q26 telomerase RNA component ARPM1 3q26.31 actin related protein M1 MYNN 3p21.3-q25.2 myoneurin MGC27085 3q26.31 hypothetical protein MGC27085 LOC344657 3q26.31 similar to RIKEN cDNA 4930558O21 FLJ23259 3q26.31 hypothetical protein FLJ23259 LOC151825 3q26.31 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SAMD7 3q26.31 sterile alpha motif domain containing 7 TLOC1 3q26.2-q27 translocation protein 1 FLJ32803 3q26.31 hypothetical protein FLJ32803 GPR160 3q26.2-q27 G protein-coupled receptor 160 LOC389176 3 similar to Histone-lysine N-methyltransferase, H4 lysine-20 specific (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7) PHC3 3q26.32 polyhomeotic like 3 (Drosophila) PRKCI 3q26.3 protein kinase C, iota SKIL 3q26 SKI-like CLDN11 3q26.2-q26.3 claudin 11 (oligodendrocyte transmembrane protein) FLJ37228 3q26.31 hypothetical protein FLJ37228 KIAA1613 3q26.31 KIAA1613 protein LOC391591 3 similar to ribosomal protein L28; 60S ribosomal protein L28 LOC200916 3q26.31 similar to RIKEN cDNA 3110001N18 EIF5A2 3q25-q27 eukaryotic translation initiation factor 5A2 SLC2A2 3q26.2-q26.3 solute carrier family 2 (facilitated glucose transporter), member 2 KIAA0551 3q26.31 Traf2 and NCK interacting kinase PLD1 3q26 phospholipase D1, phophatidylcholine-specific
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 12687 107.3 995 - Tonkin (2002)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAM (sterile alpha motif) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • polycomb gene family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text E2F6 showed nuclear colocalization in a punctate pattern that resembled the binding of polycomb bodies to heterochromatin (Deshpande 2007)
    basic FUNCTION
  • nuclear proteins that are constituents of evolutionarily conserved protein complexes designated class II PcG complexes (Isono 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the human polycomb complex PRC-H (Deshpande 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with both PRC-H complex components and with the transcription factor E2F6 (Deshpande 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in primary osteosarcoma tumors ( loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0)(Deshpande 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS