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FLASH GENE
Symbol PHC2 contributors: mct - updated : 26-09-2016
HGNC name polyhomeotic-like 2 (Drosophila)
HGNC id 3183
Location 1p35.1      Physical location : 33.789.223 - 33.841.194
Synonym name
  • early development regulator 2 (polyhomeotic 2 homolog)
  • polyhomeotic 2
  • Homo sapiens polyhomeotic homologue 2
  • Synonym symbol(s) HPH2, EDR2, MGC163502, PH2
    DNA
    TYPE functioning gene
    STRUCTURE 107.39 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC10820 1p34.3 hypothetical protein MGC10820 LCK 1p35.1 lymphocyte-specific protein tyrosine kinase HDAC1 1p34.3 histone deacetylase 1 MLP 1p34 MARCKS-like protein STK22C 1p34-p35 serine/threonine kinase 22C (spermiogenesis associated) FLJ10276 1p34.3 hypothetical protein FLJ10276 LOC343338 1p34.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ZBTB8 1p34.3 zinc finger and BTB domain containing 8 ARCH 1p34.3 archease RBBP4 1p34.3 retinoblastoma binding protein 4 SYNCOILIN 1p34.3-p33 retinoblastoma binding protein 4 KIAA1522 1p34.3 KIAA1522 protein YARS 1p34.3 tyrosyl-tRNA synthetase FLJ12903 1p34.3 hypothetical protein FLJ12903 FRCP2 HPCA 1p35-p34.2 hippocalcin BCLP 1p35-p34 beta-casein-like protein FLJ90005 1p34.3 hypothetical protein FLJ90005 LOC127545 1p34.3 similar to ribosomal protein L18a; 60S ribosomal protein L18a AK2 1p34 adenylate kinase 2 ODC-p  ornithine decarboxylase-like FLJ10759 1p34.3 hypothetical protein FLJ10759 FLJ25476 1p34.3 FLJ25476 protein LOC127550 1p34.3 similar to iGb3 synthase PHC2 1p34.3 polyhomeotic-like 2 (Drosophila) ZNF31 1p34.3 zinc finger protein 31 (KOX 29) CSMD2 1p34.3 CUB and Sushi multiple domains 2 LOC127540 1p34.3 HMG2 like MGC15882 1p34.3 hypothetical protein MGC15882
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2566 - 323 - 2004 15094067
    14 - 3873 - 858 - 2004 15094067
    - - 3789 - 830 - 2004 15094067
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a HD1 motif interacting with SAM domain of PHC1
  • a FCS-type zinc finger
  • a SAM (sterile alpha motif) domain
  • a consensus PxAxVxP motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text co-localized with SIAH1 in nuclei
    basic FUNCTION
  • mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its
  • expressibility
  • role for PHC2 in both the developing and adult brain
  • functional overlap between PHC2 and PHC1 and a strict dose-dependent requirement during anterior-posterior (A-P) specification and embryonic survival
  • basal subunits of PcG complex 1, indispensable for the early developmental events
  • may act as a negative regulator that inhibits the activity of Th cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerize with EDR1
  • component of chromatin-associated class II polycomb repressive complex 1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with N-terminal region of the SP1 transcription
  • factor as well as with MAPKAPK2
  • SIAH1 is a direct E3 ligase of PHC2 (SIAH1 interacts with PHC2 in nucleus and thereby facilitates the degradation of PHC2)
  • cell & other
    REGULATION
    Other regulated by SIAH1 (SIAH1 regulated PHC2 degradation via the ubiquitin–proteasome pathway)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS