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FLASH GENE
Symbol PHACTR4 contributors: mct - updated : 09-07-2014
HGNC name phosphatase and actin regulator 4
HGNC id 25793
Location 1p35.3      Physical location : 28.696.092 - 28.826.880
Synonym name hypothetical protein FLJ13171
Synonym symbol(s) FLJ13171, PPP1R124
DNA
TYPE functioning gene
STRUCTURE 130.79 kb     0 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 6225 - 702 - 2013 23319639
  • short isoform
  • 14 - 6208 - 712 - 2013 23319639
    long isoform
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N and Cterminal RPEL repeats, RPEL domains that mediate actin binding and the ability to bind the serine-threonine phosphatase, PP1, via their C termini
  • in the C-terminal actin and protein phosphatase-1 binding domains
  • HOMOLOGY
    interspecies homolog to murine C330013F19Rik
    Homologene
    FAMILY PHACTR family of protein phosphatase 1 (PP1)- and actin-binding proteins
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • critical for the spatially and temporally regulated transition in proliferation through differential regulation of PPP1CC and the cell cycle during neurulation and eye development
  • vmodulates integrin signaling and cofilin activity to coordinate the forces that drive enteric neural crest cell (ENCC) migration in the mammalian embryo
  • acts as a tumor suppressor that is deleted and mutant in several cancers
  • acts as a TSG to restrain cell proliferation and transformation and is inactivated in several types of cancers is a regulator of cell proliferation and exhibits characteristics of a tumor suppressor
  • inhibits protein phosphatase 1 and shows actin-binding activity
  • forms functional associations with intermediate filament networks in adult neural stem cells (NSCs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of actin to PHACTR4 influences the activity of PPP1CC and the phosphorylation status of one of its downstream targets, cofilin (pMID: 23203801)
  • ability to bind G-actin and this interaction suggests that PHACTR4 may regulate the actin cytoskeleton
  • direct binding of PHACTR4 with nestin and GFAP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS