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FLASH GENE
Symbol PGRMC2 contributors: npt - updated : 24-05-2005
HGNC name progesterone receptor membrane component 2
HGNC id 16089
Location 4q26      Physical location : 129.190.392 - 129.209.984
Synonym name
  • progesterone membrane binding protein
  • steroid receptor protein DG6
  • Synonym symbol(s) DG6, PMBP
    DNA
    TYPE functioning gene
    STRUCTURE 17.66 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1109 4q28.1 hypothetical protein KIAA1109 Tenr 4q28.1 testis nuclear RNA-binding protein IL2 4q26-q27 interleukin 2 IL21 4q26-q27 interleukin 21 FLJ35630 4q28.1 hypothetical protein FLJ35630 FGF2 4q26 fibroblast growth factor 2 (basic) NUDT6 4q26 nudix (nucleoside diphosphate linked moiety X)-type motif 6 SPATA5 4q27 spermatogenesis associated 5 SPRY1 4q26-q27 sprouty homolog 1, antagonist of FGF signaling (Drosophila) LOC391693 4 similar to ribosomal protein L21 LOC391694 4 similar to Peptidylprolyl isomerase A (cyclophilin A) LOC391695 4 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC391696 4 similar to Synaptic glycoprotein SC2 KIAA1223 4q28.1 KIAA1223 protein LOC339951 4q28.1 similar to ENSANGP00000007226 FLJ23056 4q28.1 hypothetical protein FLJ23056 LOC132817 4q28.1 similar to hypothetical protein DKFZp564O0523 KIAA1284 4q28.1 Homo sapiens KIAA1284 protein (KIAA1284), mRNA. DKFZP434N1235 4q28.2 hypothetical protein DKFZp434N1235 APG-1 4q28 heat shock protein (hsp110 family) STK18 MGC33302 4q28.2 hypothetical protein MGC33302 FLJ21106 4q28.2 hypothetical protein FLJ21106 FLJ10378 4q28.2 FLJ10378 protein PGRMC2 4q26 progesterone receptor membrane component 2 JADE1 4q26-q27 PHD protein Jade-1 FLJ30655 4q28.2 hypothetical protein FLJ30655 LOC132321 4q28.2 hypothetical protein LOC132321 LOC391697 4 similar to KIAA1511 protein LOC391698 4 similar to Eukaryotic translation elongation factor 1 gamma HCP14 4q28.2 cytochrome c, somatic pseudogene LOC391699 4 similar to alanyl trna synthetase PCDH10 4q28.3 protocadherin 10 LOC132430 4q28.3 similar to Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein-1) (APP-1) LOC345016 4q28.3 similar to Pescadillo homolog 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1873 23.8 223 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, preferentially
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative transmembrane domain
  • a highly conserved stretch of 58AA
  • HOMOLOGY
    interspecies homolog to murine Pgrmc2
    homolog to rattus 25Dx
    homolog to Drosophilia Cg9066
    intraspecies homolog to PGRMC1
    Homologene
    FAMILY
  • cytochrome b5 family
  • MAPR subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor for progesterone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • steroid (like progesterone)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS