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FLASH GENE
Symbol PGM2L1 contributors: mct/ - updated : 05-01-2011
HGNC name phosphoglucomutase 2-like 1
HGNC id 20898
Location 11q13.4      Physical location : 74.041.360 - 74.109.502
Synonym name glucose-1,6-bisphosphate synthase
Synonym symbol(s) BM32A, FLJ32029, PMMLP
EC.number 2.7.1.106
DNA
TYPE functioning gene
STRUCTURE 68.14 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 8519 - 622 - 2007 17804405
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
cell lineage
cell lines Ewing's sarcoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pgm2l1
intraspecies homolog to PGM2
Homologene
FAMILY
  • phosphohexose mutase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes
  • showing an aldose bisphosphate synthase activity with glucose 1-phosphate, deoxyribose 1-phosphate, ribose 1-phosphate, glucose 6-phosphate, and mannose 1-phosphate as substrates, but little or no activity on mannose 6-phosphate, ribose 5-phosphate
  • identified as as glucose-1,6-bisphosphate synthase
  • enzyme responsible for the synthesis of the elevated concentrations of Glc-1,6-P2 in brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS