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FLASH GENE
Symbol PGK2 contributors: mct - updated : 01-09-2011
HGNC name phosphoglycerate kinase 2
HGNC id 8898
Location 6p12.3      Physical location : 49.753.365 - 49.755.053
Synonym symbol(s) PGK-2, PGKB, PGKPS
EC.number 2.7.2.3
DNA
TYPE functioning gene
SPECIAL FEATURE
text
  • autosomal retrogene that is expressed only during spermatogenesis (
  • STRUCTURE 1.70 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    GPR110 6p21.1 G protein-coupled receptor 110 FLJ22684 6p21.1 hypothetical protein FLJ22684 TNFRSF21 6p21.1-12.2 tumor necrosis factor receptor superfamily, member 21 CD2AP 6p12 CD2-associated protein GPR111 6p12.3 G protein-coupled receptor 111 GPR115 6p12.3 G protein-coupled receptor 115 C6orf138 6p12.3 chromosome 6 open reading frame 138 LOC389395 6 similar to heterogeneous nuclear ribonucleoprotein A3 RBMXP1 6p12.3 RNA binding motif protein, X chromosome pseudogene 1 LOC391925 6 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) MUT 6p21.2-p21.1 methylmalonyl Coenzyme A mutase C6orf139 6p12.3 chromosome 6 open reading frame 139 LOC389396 6 similar to BXMAS2-10 protein C6orf141 6p12.3 chromosome 6 open reading frame 141 RHAG 6p21.1-p11 Rhesus blood group-associated glycoprotein CRISP2 6p14-q21 cysteine-rich secretory protein 2 CRISP3 6p12.3 cysteine-rich secretory protein 3 PGK2 19p13.3 phosphoglycerate kinase 2 CRISP1 6p21.2-p21.1 cysteine-rich secretory protein 1 TFAP2BL1 6p12.3 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)-like 1 TFAP2B 6p12 transcription factor AP-2 beta (activating enhancer binding protein 2 beta) RPS17L4 6p12.3 ribosomal protein S17-like 4 FTHP1 6p21.1-p12 ferritin, heavy polypeptide pseudogene 1 LOC389397 6 hypothetical gene supported by BC000383; BC004432; NM_152857 LOC391926 6 similar to 40S ribosomal protein S15a PKHD1 6p12.2 polycystic kidney and hepatic disease 1 (autosomal recessive) IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1721 - 417 - 1996 9023984
    EXPRESSION
    Rna function mRNA is translationally regulated in the mammalian testis
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage specifically, in spermatogenic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PGK1,highly
    Homologene
    FAMILY phosphoglycerate kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in glycolysis
  • key enzyme for ATP generation
  • its expression may function solely to compensate for repressed expression of the PGK1 gene due to X-chromosome inactivation in spermatocytes
  • isozyme of the glycolytic pathway that provides ATP required for sperm motility
  • isozyme that catalyzes the first ATP-generating step in the glycolytic pathway
  • not required for the completion of spermatogenesis, but is essential for sperm motility and male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTBP2 (potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells)
  • binding of PBX4, plus its coactivator PREP1, is a rate-limiting step leading to the initiation of tissue-specific transcription of the PGK2 gene
  • KHSRP serves as a decay-promoting factor for PGK2 mRNA in male germ cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activation with others testis specific retrogenes in the ovary and ovarian cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS