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FLASH GENE

Symbol

PGGT1B

contributors: mct - updated : 22-06-2018

HGNC name	protein geranylgeranyltransferase type I, beta subunit
HGNC id	8895

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q22.3      Physical location : 114.546.527 - 114.598.569
Synonym name	GGTase-I-beta
Synonym symbol(s)	GGTI, BGGI
EC.number	2.5.1.59

DNA

TYPE	functioning gene
STRUCTURE	52.04 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005023 9 - 2727 - 377 - 2010 20106865

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus         Gustatory (taste) tongue         Lymphoid/Immune lymph node         Respiratory respiratory tract larynx       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four PFTB repeats

mono polymer

heteromer

HOMOLOGY

interspecies	ortholog to murine Pggt1b
	ortholog to rattus Pggt1b

Homologene

FAMILY

protein prenyltransferase beta subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	CAAX-protein geranylgeranyltransferase activity
	attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis
	acting on the Rac1, Rac2, Rap1A and Rap1B proteins
	FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
	prenyltransferase that is responsible for lipid modification of several signaling proteins, such as RHO family small GTPase RAC1, which has been shown to be involved in neuronal morphogenesis
	potentially playing an important role in Purkinje cell development, suggesting a novel role in neuronal morphogenesis
	FNTB is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
	is involved in the posttranslational prenylation of signaling proteins, such as small GTPases
	is a key regulator of human airway smooth muscle (HASM) cell viability

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

beta subunit of protein geranylgeranyltransferase type I composed of an alpha and a beta subunit

INTERACTION

DNA

RNA

small molecule	metal binding,
	ion Zn2+ binding

protein

interacting with MIEN1 (MIEN1 contains a functional CAAX motif and is post-translationally modified by PGGT1B)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   were found in motor neurons of early- versus late-onset ALS patients postmortem

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry autism   Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia psychiatry schizophrenia   Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia

ANIMAL & CELL MODELS

mice with conditional loss of Rhoa or the gene encoding GGTase-I, Pggt1b, in intestinal epithelial cells (IECs) exhibit spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4+ T cells