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FLASH GENE
Symbol PGGT1B contributors: mct - updated : 22-06-2018
HGNC name protein geranylgeranyltransferase type I, beta subunit
HGNC id 8895
Location 5q22.3      Physical location : 114.546.527 - 114.598.569
Synonym name GGTase-I-beta
Synonym symbol(s) GGTI, BGGI
EC.number 2.5.1.59
DNA
TYPE functioning gene
STRUCTURE 52.04 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2727 - 377 - 2010 20106865
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Gustatory (taste)tongue    
Lymphoid/Immunelymph node    
Respiratoryrespiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four PFTB repeats
mono polymer heteromer
HOMOLOGY
interspecies ortholog to murine Pggt1b
ortholog to rattus Pggt1b
Homologene
FAMILY protein prenyltransferase beta subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • CAAX-protein geranylgeranyltransferase activity
  • attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis
  • acting on the Rac1, Rac2, Rap1A and Rap1B proteins
  • FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
  • prenyltransferase that is responsible for lipid modification of several signaling proteins, such as RHO family small GTPase RAC1, which has been shown to be involved in neuronal morphogenesis
  • potentially playing an important role in Purkinje cell development, suggesting a novel role in neuronal morphogenesis
  • FNTB is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
  • is involved in the posttranslational prenylation of signaling proteins, such as small GTPases
  • is a key regulator of human airway smooth muscle (HASM) cell viability
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component beta subunit of protein geranylgeranyltransferase type I composed of an alpha and a beta subunit
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+ binding
    protein interacting with MIEN1 (MIEN1 contains a functional CAAX motif and is post-translationally modified by PGGT1B)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    were found in motor neurons of early- versus late-onset ALS patients postmortem
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryautism 
    Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia
    psychiatryschizophrenia 
    Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia
    ANIMAL & CELL MODELS
  • mice with conditional loss of Rhoa or the gene encoding GGTase-I, Pggt1b, in intestinal epithelial cells (IECs) exhibit spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4+ T cells