basic FUNCTION
| CAAX-protein geranylgeranyltransferase activity |
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attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis  |
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acting on the Rac1, Rac2, Rap1A and Rap1B proteins |
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FNTB and PGGT1B are required for the homeostasis of skin keratinocytes  |
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prenyltransferase that is responsible for lipid modification of several signaling proteins, such as RHO family small GTPase RAC1, which has been shown to be involved in neuronal morphogenesis  |
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potentially playing an important role in Purkinje cell development, suggesting a novel role in neuronal morphogenesis  |
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FNTB is not dispensable and PPGT1B is crucial for the vitality of hepatocytes  |
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is involved in the posttranslational prenylation of signaling proteins, such as small GTPases  |
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is a key regulator of human airway smooth muscle (HASM) cell viability  |