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FLASH GENE
Symbol PGGT1B contributors: mct - updated : 22-06-2018
HGNC name protein geranylgeranyltransferase type I, beta subunit
HGNC id 8895
Location 5q22.3      Physical location : 114.546.527 - 114.598.569
Synonym name GGTase-I-beta
Synonym symbol(s) GGTI, BGGI
EC.number 2.5.1.59
DNA
TYPE functioning gene
STRUCTURE 52.04 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
U2AF1L1 5q22 U2(RNU2) small nuclear RNA auxillary factor 1-like 1 DCP2 5q22.3 decapping enzyme hDcp2 MCC 5q21 mutated in colorectal cancers STK22D 5q22.2 serine/threonine kinase 22D (spermiogenesis associated) LOC389316 5 LOC389316 FLJ21940 5q22.3 FLJ21940 protein KCNN2 5q22.3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 TRIM36 5q22 tripartite motif-containing 36 PGGT1B 5q23.1 protein geranylgeranyltransferase type I, beta subunit MGC39633 5q23.1 hypothetical protein MGC39633 CTNNAP1 5q22 catenin (cadherin-associated protein), alpha pseudogene 1 LOC340068 5q23.1 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) FEM1C 5q22-q23.1 fem-1 homolog c (C.elegans) TIRP 5q23.1 TRIF-related adaptor molecule CGI-109 5q23.1 CGI-109 protein CDO1 5q21-q22 cysteine dioxygenase, type I APG12L 5q21-q22 APG12 autophagy 12-like (S. cerevisiae) AP3S1 12p13.2-p13.1 adaptor-related protein complex 3, sigma 1 subunit FLJ90650 5q23.1 hypothetical protein FLJ90650 LOC389317 5 similar to 40S ribosomal protein S25 PTD002 5q23.1 PTD002 protein SEMA6A 5q23 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A RPS17P2 5q23.1 ribosomal protein S17 pseudogene 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2727 - 377 - 2010 20106865
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Gustatory (taste)tongue    
Lymphoid/Immunelymph node    
Respiratoryrespiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four PFTB repeats
mono polymer heteromer
HOMOLOGY
interspecies ortholog to murine Pggt1b
ortholog to rattus Pggt1b
Homologene
FAMILY protein prenyltransferase beta subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • CAAX-protein geranylgeranyltransferase activity
  • attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis
  • acting on the Rac1, Rac2, Rap1A and Rap1B proteins
  • FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
  • prenyltransferase that is responsible for lipid modification of several signaling proteins, such as RHO family small GTPase RAC1, which has been shown to be involved in neuronal morphogenesis
  • potentially playing an important role in Purkinje cell development, suggesting a novel role in neuronal morphogenesis
  • FNTB is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
  • is involved in the posttranslational prenylation of signaling proteins, such as small GTPases
  • is a key regulator of human airway smooth muscle (HASM) cell viability
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component beta subunit of protein geranylgeranyltransferase type I composed of an alpha and a beta subunit
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+ binding
    protein interacting with MIEN1 (MIEN1 contains a functional CAAX motif and is post-translationally modified by PGGT1B)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    were found in motor neurons of early- versus late-onset ALS patients postmortem
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryautism 
    Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia
    psychiatryschizophrenia 
    Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia
    ANIMAL & CELL MODELS
  • mice with conditional loss of Rhoa or the gene encoding GGTase-I, Pggt1b, in intestinal epithelial cells (IECs) exhibit spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4+ T cells