Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PFKFB4 contributors: - updated : 19-09-2007
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
HGNC id 8875
Location 3p22-p21      Physical location : 48.555.125 - 48.594.227
Synonym name
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4
  • bifunctional enzyme with kinase and biphosphatase activities
  • EC.number 2.7.1.105
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC391536 3 similar to 60S ribosomal protein L17 (L23) CDC25A 3p21.3 cell division cycle 25A CAMP 3p21.3 cathelicidin antimicrobial peptide SZF1 3p21 KRAB-zinc finger protein SZF1-1 MRPS18AP1 3p21.31 mitochondrial ribosomal protein S18A pseudogene 1 NME6 3p21.3 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) LOC391537 3 similar to hypothetical protein PLXNB1 3p21.31 plexin B1 FLJ12436 3p21.31 hypothetical protein FLJ12436 HSPC016 3p21.31 hypothetical protein HSPC016 TREX1 3p21.3-p21.2 three prime repair exonuclease 1 SCOTIN 3p21.31 scotin PFKFB4 3p22-p21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 SRP 3p21.3 stresscopin-related peptide COL7A1 3p21.3 collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) UQCRC1 3p21.2 ubiquinol-cytochrome c reductase core protein I LOC344651 3p21.31 hypothetical LOC344651 SLC26A6 3p21 solute carrier family 26, member 6 CELSR3 3p24.1-p21.2 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) AF3P21 3p21 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) IHPK2 3p21.31 inositol hexaphosphate kinase 2 PRKAR2A 3p21.3-p21.2 protein kinase, cAMP-dependent, regulatory, type II, alpha SLC25A20 3p21.31 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ARIH2 3p21.2-p21.3 ariadne homolog 2 (Drosophila) PH-4 3p21.31 hypoxia-inducible factor prolyl 4-hydroxylase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3503 - 469 - Minchenko
    - - 1733 - 435 - Minchenko
    - - 1724 - 278 - Minchenko
    - - 1491 - 434 - Minchenko
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • responsible for the synthesis and breakdown of fructose 2,6 biphosphate
  • key metabolite in the regulation of glycolysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS