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FLASH GENE
Symbol PFDN6 contributors: np - updated : 10-11-2003
HGNC name prefoldin subunit 6
HGNC id 4926
Location 6p21.3      Physical location : 4.489.620 - 33.258.711
Synonym name
  • HLA class II region expressed gene KE2
  • prefoldin 6
  • KE2 protein
  • Synonym symbol(s) KE-2, H2-KE2, HKE2, MGC70744, PFD6
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 605 14 129 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • suggested to contain a DNA binding leucine zipper motif
  • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine non class I-II gene Ke2 in H2-K region
    Homologene
    FAMILY
  • prefoldin beta subunit family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • binding specifically to cytosolic chaperonin (c-cpn) and transfering target proteins to it
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS