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FLASH GENE
Symbol PFDN5 contributors: npt/ - updated : 21-09-2004
HGNC name prefoldin subunit 5
HGNC id 8869
Location 12q13.13      Physical location : 53.689.234 - 53.693.232
Synonym name
  • C Myc-binding protein
  • myc modulator 1
  • prefoldin 5
  • Synonym symbol(s) MM1, MM-1, PFD5, MGC5329, MGC71907
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D12S1621 - D12S1713 - PFKM - CCNT1 - SMARCD1 - D12S1620 - PFDN5 - SLC11A2 - TFCP2 - POU6F1 - D12S361 - D12S347 - D12S368 - KRT6B - D12S96 - SP1 - D12S325 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 743 - 154 - -
    also called variant 1, isoform alpha
    4 splicing 608 - 109 - -
    also called variant 3, isoform gamma
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal putative leucine zipper motif
  • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Pfdn5
    Homologene
    FAMILY
  • prefoldin subunit alpha family
  • CATEGORY chaperone/stress , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulation of transcription, DNA-dependent
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin
  • promoting folding in an environment in which there are many competing pathways for nonnative proteins
  • repressing the transcriptional activity of c-myc and activation from promoters containing E-boxes
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN), nascent polypeptide chain, c-myc and p73
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS