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FLASH GENE
Symbol PFDN5 contributors: npt/ - updated : 21-09-2004
HGNC name prefoldin subunit 5
HGNC id 8869
Location 12q13.13      Physical location : 53.689.234 - 53.693.232
Synonym name
  • C Myc-binding protein
  • myc modulator 1
  • prefoldin 5
  • Synonym symbol(s) MM1, MM-1, PFD5, MGC5329, MGC71907
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D12S1621 - D12S1713 - PFKM - CCNT1 - SMARCD1 - D12S1620 - PFDN5 - SLC11A2 - TFCP2 - POU6F1 - D12S361 - D12S347 - D12S368 - KRT6B - D12S96 - SP1 - D12S325 - qter
    Physical map
    KRT1 12q13 keratin 1 (epidermolytic hyperkeratosis) LOC387860 12 similar to keratin 1b LOC341409 12q13.13 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 LOC387861 12 similar to K+ channel tetramerization protein HUMCYT2A 12q13.13 cytokeratin 2 KRT3 12q13 keratin 3 KRT4 12q13 keratin 4 KRT6L 12q13.13 keratin 6L K5B 12q13.13 keratin 5b KRT8 12q13 keratin 8 KRT18 12q13 keratin 18 EIF4B 12q13.13 eukaryotic translation initiation factor 4B PRO1843 12q13.13 hypothetical protein PRO1843 TENC1 12q12 tensin like C1 domain-containing phosphatase FLJ14800 12q13.13 hypothetical protein FLJ14800 IGFBP6 12q13 insulin-like growth factor binding protein 6 SOAT2 12q13.13 sterol O-acyltransferase 2 LOC387862 12 hypothetical gene supported by AK130082; NM_001416 CSAD 12q13.11-q14.3 cysteine sulfinic acid decarboxylase LOC390316 12 similar to oriLyt TD-element binding protein 7 ITGB7 12q13.2 integrin, beta 7 MGC11308 12q13.13 hypothetical protein MGC11308 ESPL1 8 extra spindle poles like 1 (S. cerevisiae) PFDN5 12q13.1 prefoldin 5 C12orf10 12q13 chromosome 12 open reading frame 10 AAAS 12q13 achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) SP7 12q12 Sp7 transcription factor SP1 12q13.1 Sp1 transcription factor AMHR2 12q13 anti-Mullerian hormone receptor, type II DKFZP564J157 12q12 DKFZp564J157 protein PCBP2 12q13.12-q13.13 poly(rC) binding protein 2 MAP3K12 12q13 mitogen-activated protein kinase kinase kinase 12 TARBP2 12q12-q13 TAR (HIV) RNA binding protein 2 NPFF 12q13.13 neuropeptide FF-amide peptide precursor FLJ30317 12q13.13 hypothetical protein FLJ30317 ATF7 12q13 activating transcription factor 7 LOC341412 12q13.13 similar to ribosomal protein L31 ATP5G2 12q13.13 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 KIAA1536 12q13.13 KIAA1536 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 743 - 154 - -
    also called variant 1, isoform alpha
    4 splicing 608 - 109 - -
    also called variant 3, isoform gamma
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal putative leucine zipper motif
  • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Pfdn5
    Homologene
    FAMILY
  • prefoldin subunit alpha family
  • CATEGORY chaperone/stress , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulation of transcription, DNA-dependent
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin
  • promoting folding in an environment in which there are many competing pathways for nonnative proteins
  • repressing the transcriptional activity of c-myc and activation from promoters containing E-boxes
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN), nascent polypeptide chain, c-myc and p73
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS