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FLASH GENE
Symbol PFAS contributors: - updated : 11-07-2007
HGNC name phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
HGNC id 8863
Location 17p13.1      Physical location : 8.152.595 - 8.173.808
Synonym name
  • FGAR amidotransferase
  • formylglycinamide ribotide amidotransferase
  • formylglycinamide ribotide synthetase
  • Synonym symbol(s) FGARAT, KIAA0361, FGAMS, PURL
    EC.number 6.3.5.3
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 21.00 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC92162 17p13.2 similar to RIKEN cDNA 2600017H02 MGC14151 17p13.2 hypothetical protein MGC14151 FLJ32499 17p13.2 hypothetical protein FLJ32499 LOC388331 17 LOC388331 KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans) MYH10 17p13.1 myosin, heavy polypeptide 10, non-muscle
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the fourth step of the de novo purine biosynthesis,leading to formyl glycinamidine ribonucleotide (FGAM)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS