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FLASH GENE
Symbol PF4V1 contributors: mct - updated : 20-05-2009
HGNC name platelet factor 4 variant 1
HGNC id 8862
Location 4q13.3      Physical location : 74.719.012 - 74.720.198
Synonym name
  • C-X-C motif chemokine 4 variant
  • platelet factor 4, variant 1 (PF4-like)
  • Synonym symbol(s) PF4A, CXCL4V1, PF4-ALT, SCYB4V1, CXCL4L1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 1.19 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Text see IMC2@
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 741 11.42 104 - 2004 15459074
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid Hydrophobic
    STRUCTURE
    motifs/domains
  • a 34-amino acid hydrophobic leader sequence
  • a 42-amino acid segment
  • 28-residue carboxy-terminal region corresponding to a domain specifying heparin-binding and cellular chemotaxis
  • HOMOLOGY
    interspecies homolog to C.elegans K03D3.5
    Homologene
    FAMILY
  • platelet factor 4 family
  • intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text continuously synthesized and secreted through a constitutive pathway
    basic FUNCTION
  • more potent as PF4 in inhibiting chemotaxis of microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF)
  • activated platelets release and potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS