Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PEX16

contributors: mct - updated : 05-09-2014

HGNC name	peroxisomal biogenesis factor 16
HGNC id	8857

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PBD9 peroxisome biogenesis disorder 9, Zellweger spectrum
Location	11p11.2      Physical location : 45.931.220 - 45.939.674
Synonym symbol(s)	HGNC8857

DNA

TYPE	functioning gene
STRUCTURE	8.45 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004813 11 splicing 1929 NP_004804 38 336 - 2006 16717127 NM_057174 11 - 1794 NP_476515 - 346 - 2006 16717127

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine neuroendocrine pituitary       Reproductive female system uterus cervix       female system breast mammary gland     Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Pex16
	homolog to dog LOC483639

Homologene

FAMILY

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,peroxisome
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	playing a central role in peroxisomal membrane biogenesis, more likely updtream PEX3
	implicated in the origin and maintenance of peroxisomes involving a de novo PEX16-dependent pathway from the Endoplasmic reticulum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PEX19
	PEX3 requires PEX16 for ER location but is dispensable for the ER location of PEX16
	SEC16B plays an important role in the transport of PEX16 from the ER to peroxisomes in mammalian cells
	PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and SLC25A17, via the ER

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PBD9

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS