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FLASH GENE
Symbol PEX16 contributors: mct - updated : 05-09-2014
HGNC name peroxisomal biogenesis factor 16
HGNC id 8857
Corresponding disease
PBD9 peroxisome biogenesis disorder 9, Zellweger spectrum
Location 11p11.2      Physical location : 45.931.220 - 45.939.674
Synonym symbol(s) HGNC8857
DNA
TYPE functioning gene
STRUCTURE 8.45 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390111 11 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) KAI1 11p11.2-p11.13 kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) LOC387764 11 LOC387764 LOC90139 11p11.2 tetraspanin similiar to uroplakin 1 TP53I11 11pter-p15.5 tumor protein p53 inducible protein 11 PRDM11 11p11 PR domain containing 11 LOC219638 11p11.2 similar to KIAA0543 protein SYT13 11p12-p11 synaptotagmin XIII CHST1 11p11.2-p11.1 carbohydrate (keratan sulfate GAL-6) sulfotransferase 1 DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 1929 38 336 - 2006 16717127
11 - 1794 - 346 - 2006 16717127
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Endocrineneuroendocrinepituitary   
Reproductivefemale systemuteruscervix  
 female systembreastmammary gland  
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Pex16
homolog to dog LOC483639
Homologene
FAMILY
CATEGORY regulatory , structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,peroxisome
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • playing a central role in peroxisomal membrane biogenesis, more likely updtream PEX3
  • implicated in the origin and maintenance of peroxisomes involving a de novo PEX16-dependent pathway from the Endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEX19
  • PEX3 requires PEX16 for ER location but is dispensable for the ER location of PEX16
  • SEC16B plays an important role in the transport of PEX16 from the ER to peroxisomes in mammalian cells
  • PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and SLC25A17, via the ER
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBD9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS