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FLASH GENE
Symbol PER3 contributors: mct - updated : 08-07-2011
HGNC name period homolog 3 (Drosophila)
HGNC id 8847
Location 1p36.23      Physical location : 7.844.762 - 7.905.236
Synonym name
  • period circadian protein 3
  • growth-inhibiting protein 13
  • circadian clock protein PERIOD 3
  • Synonym symbol(s) RP3-467L1.3, GIG13
    DNA
    TYPE functioning gene
    STRUCTURE 60.52 kb     21 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 6203 - 1201 - -
    EXPRESSION
    Rna function photoreceptor
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Nervousbraindiencephalonhypothalamussuprachiasmatic nuclei 
     nervecranial nerve  highly
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic helix loop helix (bHLH)
  • two PAS dimerization domains
  • one PAS associated C terminal domain
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to Drosophila period gene
    homolog to murine Per
    Homologene
    FAMILY
  • basic helix loop helix family of transcription factors
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator of circadian rhythms in and outside the brain
  • checkpoint protein that plays important roles in checkpoint activation, cell proliferation and apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , circadian
    text rhythmic behavior
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PER3 physically interacted with ATM and CHEK2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated expression in in chronic myeloid leukemia correlated with the inactivation by methylation
    Susceptibility to bipolar disorder
    Variant & Polymorphism other polymorphisms increasing the bipolar disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS