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FLASH GENE
Symbol PELO contributors: mct/npt - updated : 11-02-2012
HGNC name pelota homolog (Drosophila)
HGNC id 8829
Location 5q11.2      Physical location : 52.083.773 - 52.098.449
Synonym symbol(s) CGI-17, PRO1770
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text embedded within ITGA1 intron 1
STRUCTURE 14.68 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure two Sp1 binding elements
MAPPING cloned Y linked N status provisional
Physical map
MGC71745 5q11.2 similar to embigin LOC202319 5q11.2 similar to cyclophilin-LC; cyclophilin homolog overexpressed in liver cancer; chromosome 1 amplified sequence 2 FLJ21308 5q11.2 hypothetical protein FLJ21308 LOC153630 5q11.2 hypothetical LOC153630 LOC133569 5q11.2 similar to 40S ribosomal protein S10 ISL1 5q11.1 ISL1 transcription factor, LIM/homeodomain, (islet-1) PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2000 - - testis 2000 11060452
3 - 2941 - 385 ubiquitous 2000 11060452
1 - 4811 - 1179 - 2000 11060452
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemuterus  highly
 male systemtestis   
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila pelota
    homolog to S. cerevisiae Dom34
    Homologene
    FAMILY
  • eukaryotic release factor 1 family
  • Pelota subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • localized at the actin cytoskeleton
  • basic FUNCTION
  • involved in cell cycle regulation
  • required for patterning in the eye and mitotic divisions in the ovary
  • involved in repressing a Bam-independent differentiation pathway
  • potential direct catalytic role in no-go mRNA decay
  • having inter-domain structural plasticity, suggesting that large conformational changes are essential for its functions
  • involved in the regulation of cell proliferation and stem cell self-renewal
  • binding to cytoskeleton-associated proteins may facilitate PELO to detect and degrade aberrant mRNAs, at which the ribosome is stalled during translation
  • protein complex of Pelota and HBS1L translational GTPase recognizes the stalled ribosome containing the defective mRNA
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the integrin collagen receptor locus ITGA1-PELO-ITGA2
  • Pelota/HBS1L induced dissociation of elongation complexes and release of peptidyl-tRNA, but only in the presence of ABCE1
  • ABCE1/Pelota/HBS1L also dissociated vacant 80S ribosomes, which stimulated 48S complex formation, suggesting that Pelota/HBS1L have an additional role outside of stable secondary structures (NGD)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pelo-deficient mice die early during gastrulation due to defects in cell proliferation and/or differentiation