basic FUNCTION
| promoting activation of C-Jun and ELK-1 and may be acting as a scaffolding protein |
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playing an important role in the innate immune response |
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implicated as evolutionary conserved scaffold proteins in TLR/IL-1R signaling leading to nuclear factor-kappaB and mitogen activated protein kinase-dependent gene expression |
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E3 ligases that can catalyze Lys(63)-linked polyubiquitination but also shows bidirectional signaling between the IRAK and Pellino families and highlights a novel function for IRAK kinase activity |
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PELI1, PELI2, PELI3 are novel RING E3 ubiquitin ligases involved in IRAK1 polyubiquitination and degradation |
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PELI2, PELI3 (to a much lesser degree Pellino 1) carry the E3 ubiquitin ligase activity and promote polyubiquitination on IRAK1 |
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induce IRAK1 polyubiquitination in a RING-dependent manner |
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is a novel regulator of TNF signalling and an important determining factor in dictating whether TNF induces cell survival or death |
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PELI1, PELI2, PELI3 E3 ubiquitin ligases are emerging as critical mediators for a variety of immune signaling pathways, including those activated by Toll-like receptors, the T-cell receptor, and NOD2 |
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nonredundant roles that PELI1, PELI2, PELI3 play in immune signaling are in part due to their divergent substrate specificities |
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E3 ubiquitin ligase and scaffold protein in TLR4-signaling, impacted by autophagy in macrophages after LPS stimulation |