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FLASH GENE
Symbol PEG10 contributors: mct/pgu - updated : 21-02-2012
HGNC name paternally expressed 10
HGNC id 14005
Location 7q21.3      Physical location : 94.285.636 - 94.299.004
Synonym name
  • murine myelin expression factor 3 homolog
  • embryonal carcinoma differentiation regulated 2
  • MEF3-like protein 1
  • myelin expression factor 3-like protein 1
  • paternally expressed gene 10 protein
  • retrotransposon-derived gag-like polyprotein
  • Ty3/Gypsy-like protein
    • Synonym symbol(s) KIAA1051, HB1, MEF3L, HB-1, RGAG3, Mar2, Mart2, EDR
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text contains two overlapping open reading frames (ORF1 and ORF2)
    STRUCTURE 13.37 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • PEG10 translation is initiated at a non-AUG start codon upstream of the previously predicted AUG codon as well as at the AUG codon
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • codes for at least two proteins, PEG10-RF1 and PEG10-RF1/2, by -1 frameshift translation (PMID: 20084274)
    • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6628 - 708 - 2010 20084274
  • RF1/RF2
    • 2 - 6628 - 325 - 2010 20084274
  • RF1
  • is an inhibitor of apoptosis and mediates cell proliferation
    • 2 - 6628 - 742 - 2010 20084274
  • RF1/RF2
    • 2 - 6628 - 359 - 2010 20084274
  • RF1
  • is an inhibitor of apoptosis and mediates cell proliferation
    • 2 - 6602 - 784 - 2010 20084274
  • RF1/RF2
    • 2 - 6602 - 401 - 2010 20084274
  • RF1
  • is an inhibitor of apoptosis and mediates cell proliferation
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouthtongue  highly
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  highly
     female systemovary  highly
     male systemtestis  highly
    Respiratorylung   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    IMPRINTING maternally
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CCHC type zinc finger motif
    • HOMOLOGY
    interspecies homolog to murine myelin expression factor 3
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text distributed in the cytosol and associates with the nuclear membrane
    basic FUNCTION
  • may play an important role during liver regeneration or carcinogenesis of the hepatocyte
  • decreasing the cell death mediated by SIAH1
  • plays a crucial role at the immediate early stage of adipocyte differentiation
  • showing significant oncogenic function in both solid tumors and B cell acute and chronic lymphocytic leukemia through its apparent ability to prevent apoptosis and promote cell proliferation
  • involved in the repression of apoptosis induced by serum deprivation and chemotherapeutic drugs
  • expressing two reading frames by high efficiency and frameshifting in embryonic-associated tissues
  • promote adipocyte differentiation
  • probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of hepatocellular carcinoma
  • play a role in fetal growth and placental development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH1
  • E2F acts directly upstream of an anti-apoptosis imprinted gene, PEG10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a great majority of hepatocellular carcinomas
    tumoral     --over  
    from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia BCLL
    constitutional     --low  
    in third trimester downregulated in fetal samples group
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • represents a novel marker in B-CLL
  • for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
    • Marker
  • positive expression of PEG10 or TSG101 is a predictor of poor prognosis in gallbladder adenocarcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
    ANIMAL & CELL MODELS