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FLASH GENE
Symbol PEF1 contributors: npt/mct - updated : 07-01-2009
HGNC name penta-EF-hand domain containing 1
HGNC id 30009
Location 1p34      Physical location : 32.095.462 - 32.110.838
Synonym name
  • penta-EF-hand protein
  • protein with a long N-terminal hydrophobic domain
  • peflin
  • Synonym symbol(s) ABP32, PEF1A, PEFLIN, PEF
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1640 30 284 - Clark (2003)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • five EF hand calcium binding motif
  • monopeptide repeat at the N terminus
  • one calpain catalytic domain
  • HOMOLOGY
    intraspecies homolog to ALG2
    Homologene
    FAMILY
  • penta-EF hand (PEF) family of calcium binding proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • modulating the function of PDCD6 in calcium signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with PDCD6
  • dimerization with ALG2 (stabilized by dimerization through their fifth EF-hand regions)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein interacting with SRI, GCA (heterodimerization, in addition to differential interactions with target proteins, might be a way to regulate and fine tune processes mediated by calcium binding proteins of the penta-EF hand type)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS