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FLASH GENE
Symbol PECR contributors: npt - updated : 23-09-2006
HGNC name peroxisomal trans-2-enoyl-CoA reductase
HGNC id 18281
Location 2q35      Physical location : 216.903.110 - 216.946.539
Synonym name
  • peroxisomal NADPH-specific trans-2-enoyl CoA reductase
  • putative short chain alcohol dehydrogenase
  • 2,4-dienoyl-CoA reductase-related protein
  • Synonym symbol(s) TERP, T2ECR, HSA250303, DCR-RP, HPDHase, pVI-ARL
    EC.number 1.3.1.38
    DNA
    TYPE functioning gene
    STRUCTURE 43.40 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1901 32.5 303 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   highly
    Nervousbrain    
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • peroxisomal targeting signal (AKL)
  • C terminus short chain dehydrogenase/reductase
  • HOMOLOGY
    interspecies ortholog to murine Pecr
    homolog to Drosophila CG1696
    homolog to C.elegans F45E12.1
    Homologene
    FAMILY
  • 3 beta hydroxysteroid dehydrogenase/isomerase family
  • short-chain deshydrogenase/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • fatty acids chain elongation pathway
  • reducing trans-2-enoylCoAs of from 6:1 to 16:1
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text apoptosis regulator
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    enterobactin biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS