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FLASH GENE
Symbol PEBP4 contributors: mct - updated : 10-06-2009
HGNC name phosphatidylethanolamine-binding protein 4
HGNC id 28319
Location 8p21.3      Physical location : 22.570.764 - 22.785.421
Synonym name cousin-of-RKIP 1 protein
Synonym symbol(s) CORK-1, CORK1, GWTM1933, MGC22776, PRO4408, PEBP-4
DNA
TYPE functioning gene
STRUCTURE 214.66 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 901 - 227 - 2006 16865237
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • RAF kinase inhibitory protein (RKIP) family
  • phosphatidylethanolamine-binding protein family
    • CATEGORY receptor kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulates the activity of the ERK pathway and myoblast differentiation by acting as a scaffold protein
  • participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms ternary complexes with RAF1 and MEK, and can scaffold this interaction
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to RAF1 and MEK
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast and ovarian cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target silencing of PEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer
    ANIMAL & CELL MODELS
    mPEBP4 is specifically expressed in retinal ganglion cells