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FLASH GENE
Symbol PEAK1 contributors: mct - updated : 21-08-2014
HGNC name pseudopodium-enriched atypical kinase 1
HGNC id 29431
Location 15q24.3      Physical location : -
Synonym name
  • sugen kinase 269
  • tyrosine-protein kinase SgK269
  • Synonym symbol(s) SGK269
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 311.95 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 11834 - 1746 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • tyrosine kinase that associates with the actin cytoskeleton and focal adhesion (FA) in migrating cells
  • plays an instrumental role in regulating the formation, maturation, and disassembly of FAs, which are pivotal for cell migration
  • with LYN is involved in a basal breast cancer signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel SFK-dependent focal adhesion (FA) regulator
  • PEAK1 and SRC work cooperatively to promote cell migration and invasion which has important implications for cancer metastasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    n a subset of basal, HER2-positive, and luminal breast cancers
    tumoral     --over  
    in human pancreatic and colon cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a novel biomarker, and critical signaling hub inpancreatic ductal adenocarcinoma (PDAC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    disrupting PEAK1-SRC activities could be a fruitful avenue for therapeutic cancer treatment
    cancerdigestivepancreas
    new therapeutic target in pancreatic ductal adenocarcinoma (PDAC)
    ANIMAL & CELL MODELS