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FLASH GENE
Symbol PDXP contributors: mct - updated : 27-11-2018
HGNC name pyridoxal phosphatase
HGNC id
Location 22q13.1      Physical location : 38.054.736 - 38.062.939
Synonym name
  • cofilin phosphatase chronophin
  • Synonym symbol(s) CIN, PLP, dJ37E16.5, FLJ32703, PLPP
    EC.number 3.1.3.3/ 3.1.3.74
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text
  • brain-specific RhoGAP splice variant, BARGIN (BGIN), which comprises a combination of BAR, GAP, and partial PDXP phosphatase domains spliced from adjacent SH3BP1 and PDXP gene loci (23223568)
  • STRUCTURE 8.20 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2072 - 296 - 2013 23223568
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • is crucial for the balance of protrusion/retraction events during cell migration
  • may be an important factor for regulating the plasticity threshold
  • is involved in the fine-tuning of GABA biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates an ATP-sensing mechanism for CFL1 dephosphorylation and neuronal CFL1-actin rod formation
  • spatiotemporally PDXP regulates cofilin activity at the cell edge to generate persistent membrane extension
  • enhanced N-methyl-D-aspartate receptor (GluN) functionality by regulating the coupling of GRIN2A with interacting proteins, particularly postsynaptic density-95 (DLG4)
  • PDXP acts as a major regulator of cellular Pyridoxal 5'-phosphate (PLP) concentrations
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    pharmacological inhibition of PDXP might correct the excitatory/inhibitory imbalance in some neuropsychiatric diseases
    ANIMAL & CELL MODELS
  • behavioral phenotyping of PDXP knockout mice revealed improved spatial learning and memory, and a mild anxiety-like behavior