basic FUNCTION
| key regulator of pancreatic islet development and insulin gene transcription |
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involved in islet beta cell function and formation |
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playing a critical role for the initiation of all pancreatic lineages |
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may inhibit the ductal differentiation program in the pancreatic endocrine compartment, particularly beta cells |
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transcription factor, necessary for differentiation of exocrine and endocrine pancreas, and regulating insulin gene transcription |
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regulates cell proliferation and invasion in human pancreatic cancer cells |
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plays a crucial role in pancreas development and beta-cell differentiation, and maintaining mature beta-cell function |
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functions as a putative tumor suppressor in gastric cancer |
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transcription factor that critically regulates early pancreas formation and multiple aspects of mature beta cell function, including insulin secretion, mitochondrial metabolism, and cell survival |
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homeodomain transcription factor, that serves as a master regulator in the pancreas because of its importance during organogenesis and in adult islet insulin-producing beta cell activity |
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recruits EP300 and enhances the transcriptional activity of PDX1, which results in the stimulation of insulin secretion in response to high glucose levels |
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plays a critical role during beta-cell development and in glucose-induced insulin gene transcription in adult beta-cells |
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nuclear localization of PDX1 is essential for a functional beta-cell, providing a novel mechanism of the protective effect of IL1R1 antagonist on beta-cell survival and function |
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MAFA, PDX1 and NEUROG3 (an upstream regulator of Beta2/NEUROD1) leads to the effective reprogramming of acinar cells into insulin-producing beta cells |
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plays an essential role in pancreatic development and in maintaining proper islet function via target gene regulation |
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potential role for PDX1 in patterning anterior intestinal development |
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is not necessary for the postnatal formation of & |
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946;-cells but is essential for their full maturation to glucose-responsive beta-cells |
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key regulator of pancreas and foregut development |
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key role in maintaining the integrity and function of insulin-secreting beta cells in the adult pancreas |
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PDX1, NEUROG3 and MAFA, are very important in pancreatic development |