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FLASH GENE

Symbol

PDS5A

contributors: npt/mct - updated : 05-12-2017

HGNC name	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
HGNC id	29088

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p14      Physical location : 39.824.483 - 39.979.576
Synonym name	cDNA sequence, expressed in brain, >100kDa, related to E nidulary BIMD protein VII
	SCC-112 protein
	sister chromatid cohesion protein 112
	cell proliferation-inducing protein 54
Synonym symbol(s)	KIAA0648, FLJ41012, SCC-112, PIG54, DKFZp686B19246, MGC131948, MGC161503, PDS5

DNA

TYPE	functioning gene
STRUCTURE	155.10 kb     33 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001100399 33 - 7190 NP_001093869 151 1337 - Zheng (2008) NM_015200 33 - 6726 NP_056015 - 1297 - Zheng (2008) NM_001100400 16 - 2745 NP_001093870 - 600 - Zheng (2008)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive male system testis     highly Urinary bladder       highly   kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum cardiac

cell lineage
cell lines	lung carcinoma
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RhoGEF domain
	a leucine zipper domain
	an N-adaptin domain
	a SKP1 domain
	three PEST sequences
	six nuclear localization signals
	two sites for tyrosine phosphorylation

HOMOLOGY

intraspecies

homolog to E nidulary BIMD protein VII

Homologene

FAMILY

PDS5 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	cell cycle-regulated molecule, likely associated with normal cell growth and proliferation
	involved in tumor progression and promotes the cell proliferation in G2/M phase (Zheng 2008)
	PDS5A and PDS5B functions other than those involving chromosomal dynamics are important for normal development, highlights the sensitivity of key developmental processes on PDS5 signaling (Zhang 2009)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	WAPL is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (PDS5A, PDS5B) to promote cohesin release from chromatin
	in mitosis, WAPL-mediated release of cohesin from DNA is

INTERACTION

DNA

RNA

small molecule

protein

through binding the cohesin subunit PDS5A, WAPAL releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin is protected from WAPAL until anaphase onset

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS