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FLASH GENE
Symbol PDS5A contributors: npt/mct - updated : 05-12-2017
HGNC name PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
HGNC id 29088
Location 4p14      Physical location : 39.824.483 - 39.979.576
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to E nidulary BIMD protein VII
  • SCC-112 protein
  • sister chromatid cohesion protein 112
  • cell proliferation-inducing protein 54
  • Synonym symbol(s) KIAA0648, FLJ41012, SCC-112, PIG54, DKFZp686B19246, MGC131948, MGC161503, PDS5
    DNA
    TYPE functioning gene
    STRUCTURE 155.10 kb     33 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 7190 151 1337 - Zheng (2008)
    33 - 6726 - 1297 - Zheng (2008)
    16 - 2745 - 600 - Zheng (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumcardiac  
    cell lineage
    cell lines lung carcinoma
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RhoGEF domain
  • a leucine zipper domain
  • an N-adaptin domain
  • a SKP1 domain
  • three PEST sequences
  • six nuclear localization signals
  • two sites for tyrosine phosphorylation
  • HOMOLOGY
    intraspecies homolog to E nidulary BIMD protein VII
    Homologene
    FAMILY
  • PDS5 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • cell cycle-regulated molecule, likely associated with normal cell growth and proliferation
  • involved in tumor progression and promotes the cell proliferation in G2/M phase (Zheng 2008)
  • PDS5A and PDS5B functions other than those involving chromosomal dynamics are important for normal development, highlights the sensitivity of key developmental processes on PDS5 signaling (Zhang 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WAPL is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (PDS5A, PDS5B) to promote cohesin release from chromatin
  • in mitosis, WAPL-mediated release of cohesin from DNA is
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • through binding the cohesin subunit PDS5A, WAPAL releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin is protected from WAPAL until anaphase onset
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS