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FLASH GENE
Symbol PDLIM1 contributors: mct/pgu - updated : 03-07-2018
HGNC name PDZ and LIM domain 1 (elfin)
HGNC id 2067
Location 10q23.3      Physical location : 96.997.331 - 97.050.781
Synonym name
  • carboxy terminal LIM domain protein 1
  • elfin
  • human LIM domain protein CLP-36 mRNA, complete cds
  • enigma
  • epididymis secretory protein Li 112
  • Synonym symbol(s) CLIM1, CLP36, PDL1, CLP-36, LIM-HD, hCLIM1, HEL-S-112
    DNA
    TYPE functioning gene
    STRUCTURE 53.45 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein HELLS 10q23-q24 helicase, lymphoid-specific CYP2C18 10q24 cytochrome P450, family 2, subfamily C, polypeptide 18 CYP2C19 10q24 cytochrome P450, family 2, subfamily C, polypeptide 19 CYP2C9 10q24.1 cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C8 10q23.33 cytochrome P450, family 2, subfamily C, polypeptide 8 LOC387705 10 LOC387705 LOC142827 10q24.1 similar to Hypothetical protein MGC56918 PDLIM1 10q22-q26.3 PDZ and LIM domain 1 (elfin) SORBS1 10q23.3-q24.1 sorbin and SH3 domain containing 1 LOC389999 10 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 PYCS 10q24.3 pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) DKFZP564D116 10q24.1 DKFZP564D116 protein ENTPD1 10q24 ectonucleoside triphosphate diphosphohydrolase 1 LOC387706 10 LOC387706 LOC387707 10 similar to RIKEN cDNA 5730509K17 gene FLJ10895 10pter-q26.12 hypothetical protein FLJ10895 KIAA0335 10cen-q26.11 hypothetical protein FLJ10895 LOC387708 10 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 BLNK 10q23.2 B-cell linker DNTT 10q24 deoxynucleotidyltransferase, terminal TMEM10 10q23-q24 transmembrane protein 10 TLL2 10q23-q24 tolloid-like 2 SMBP 10q24.2 SM-11044 binding protein PIK3AP1 10q24.2 phosphoinositide-3-kinase adaptor protein 1 LOC283340 10q24.2 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387709 10 LOC387709 C10orf12 10q24.2 chromosome 10 open reading frame 12 SLIT1 10q23.3-q24 slit homolog 1 (Drosophila) ARHGAP19 10q24.2 Rho GTPase activating protein 19 FRAT1 10q24.1 frequently rearranged in advanced T-cell lymphomas
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1462 36.1 329 - 2006 16609848
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
     pharynx   highly
    Endocrinepancreas   lowly
    Lymphoid/Immunespleen   highly
     tonsils   highly
    Nervousgangliasensory gangliadorsal root highly Homo sapiens
    Reproductivefemale systemplacenta  highly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, exclusively expressed in the cytotrophoblast layer
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal PDZ motif, essential for CLP36 to function
  • LIM domain at the C terminus, essential for CLP36 to function
  • HOMOLOGY
    interspecies ortholog to rattus Clp36
    Homologene
    FAMILY
  • ALP subfamily of PDZ-LIM proteins
  • enigma family of proteins
  • CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • PDLIM1 and palladin were colocalized in the neurites and cell bodies of primary DRG neurons
  • forms a complex with alpha-actinin and is localized to actin cytoskeleton
  • in platelets, the PDZ domain of PDLIM1 has been shown to build a bridge between stress fibers and ACTN1 and to link plasma membrane Ca2+ ATPase 4b to the actin cytoskeleton
  • basic FUNCTION
  • cytoskeletal protein acting as an adaptor that brings other proteins to the cytoskeleton
  • involved in the cytoskeletal reorganization and signal transduction of a variety of cells
  • playing an essential role for the assembly of stress fibers and focal adhesions
  • regulate the biological activity of ESR1 during the development of breast cancer
  • serves as a scaffold to form a multiprotein complex that regulates actin cytoskeleton dynamics and plays a role in controlling neurite outgrowth
  • plays a role in neurite outgrowth in the peripheral nervous system
  • may interact with palladin to influence neurite outgrowth during sciatic nerve regeneration
  • is dispensable for actin rearrangements in platelets
  • is an important regulator of platelet activation
  • is an important regulator of breast cancer cell migration and metastasis
  • PDLIM1 suppresses EMT and metastatic potential of colorectal cancer cells by stabilizing CTNNB1 at cell-cell junctions
  • degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ectoplasmic specialization (ES), and these findings define a novel role for autophagy in Sertoli cell-germ cell communication
  • autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • PDLIM1 and palladin formed a complex in the dorsal root ganglion (DRG)
  • FHL1 exists as part of a complex that binds with PDLIM1, GSN and ACTN1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-activing 1, 2, 4-(ACTN1, ACTN2, ACTN4)
  • PALLD is a PDLIM1-binding protein
  • acts as a negative regulator of GP6 signaling, and acts as a negative regulator of GP6 signaling also under flow
  • PDLIM1 negatively regulates NFKB1-mediated signaling in the cytoplasm (PDLIM1 sequestered p65 subunit of NFKB1 in the cytoplasm and suppressed its nuclear translocation in an NFKBIA-independent, but ACTN4-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    up-regulated in dorsal root ganglion neurons and facial motoneurons after nerve injury
    constitutional       loss of function
    results in markedly enhanced platelet activation in response to collagen and a prothrombotic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PDLIM1 loss in metastatic tissues may represent a potential prognostic marker of aggressive disease
  • Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    might provide a basis for the development of novel strategies to control intravascular platelet activation
    ANIMAL & CELL MODELS