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FLASH GENE
Symbol PDK4 contributors: mct/npt - updated : 21-12-2017
HGNC name pyruvate dehydrogenase kinase, isoenzyme 4
HGNC id 8812
Location 7q21.3      Physical location : 95.212.814 - 95.225.925
Synonym name lipoamide kinase isozyme 4, mitochondrial
Synonym symbol(s) PDHK4, FLJ40832
EC.number 2.7.1.99, 2.7.11.2
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • p300/CBP may enhance acetylation of histones bound to the promoter and cooperate with Sp1 and CBF (CCAAT box binding factor) to stimulate transcription of the PDK4 gene in response to retinoic acids (RA) as well as Trichostatin A (TSA)
  • MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3710 46.5 411 - Tsintzas (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix  
    Respiratoryrespiratory tracttrachea  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • histidine-kinase domain
  • HOMOLOGY
    interspecies homolog to murine Pdk4
    Homologene
    FAMILY
  • pdk/bckdk protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • pyruvate dehydrogenase kinase 4, regulating mitochondrial PDH activity
  • with PDK3 and PDK2 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
  • regulation of glycolysis by PDK2, PDK4 functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FOXO1 to regulate energetic metabolism
  • PDK2 and PDK4, key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy
  • cell & other
    REGULATION
    induced by CEBPB (induced PDK4 gene expression and decreased PDC activity)
    Other regulated by retinoic acids (RA) as well as Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in tissues other than the liver is clearly important during starvation for regulation of PDC (pyruvate dehydrogenase complex) activity and glucose homoeostasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS