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FLASH GENE
Symbol PDK2 contributors: mct/npt - updated : 19-12-2017
HGNC name pyruvate dehydrogenase kinase, isozyme 2
HGNC id 8810
Location 17q21.33      Physical location : 48.172.695 - 48.188.422
Synonym name
  • pyruvate dehydrogenase kinase, isoenzyme 2
  • pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
  • pyruvate dehydrogenase kinase 2
    • Synonym symbol(s) PDHK2, PDKII
    EC.number 2.7.11.2
    DNA
    TYPE functioning gene
    STRUCTURE 16.63 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Map cen - D17S806 /D17S1859 - HOXB3 - ATP6V0A1 - GIP - GNGT2 - PHB - NGFR - D17S1795 - qter
    Authors Mohlke (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2319 - 407 - 2017 28178523
    12 - 2712 - 343 - 2017 28178523
    4 - 987 - 199 - 2017 28178523
    11 - 2511 - 343 - 2017 28178523
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Endocrinepancreas   lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta lowly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal DW-motif playing a role in mediating communications between the dichloroacetate -, the nucleotide-, and the lipoyl domain-binding sites (Li 2009)
    • HOMOLOGY
    interspecies homolog to murine Pdk2
    homolog to C.elegans zk370.5
    Homologene
    FAMILY
  • PDK/BCKDK protein kinase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • inhibition of the mitochondrial pyruvate dehydrogenase complexe by phosphorylation of the E1 alpha subunit
  • with PDK3 and PDK4 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
  • regulation of glycolysis by PDK2, PDK4 functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
  • PDK1 and PDK2 promote meiotic maturation, as their knockdown disturbs the assembly of the meiotic apparatus, without significantly altering ATP content
  • PDK2 and PDK4, key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy
  • preliminary positive role and potential mechanisms of PDK2 in chondrogenic differentiation of mesenchymal stem cells (MSCs)
  • promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of SOX6 and activation of JNK/MAPK/ERK pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with OSBP9L (PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
  • wild-type TP53 prevents manifestation of the Warburg effect by controlling PDK2
  • mitochondrial activation by inhibition of PDK2 suppresses HIF1a signaling and angiogenesis in cancer
  • PDK2, a key regulator in metabolic plasticity, phosphorylates PARL and regulates beta cleavage
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    is a potential therapeutic target for nonalcoholic fatty liver disease
    ANIMAL & CELL MODELS