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FLASH GENE
Symbol PDILT contributors: mct/npt - updated : 10-12-2013
Location 16p12.3      Physical location : 20.370.491 - 20.416.033
Genatlas name protein disulfide isomerase-like protein of the testis
Synonym name
  • protein disulfide isomerase family A, member 7
    • Synonym symbol(s) PDIA7
    DNA
    TYPE functioning gene
    STRUCTURE 45.57 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2195 66 584 - 2005 15475357
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text ubiquitously expressed during development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two thioredoxin domains
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • protein disulfide isomerase family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having specialized chaperone function in testicular cells
  • catalyzing the rearrangement of -s-s- bonds in proteins
  • first eukaryotic SXXC protein to be characterized in the ER
  • ER resident glycoprotein that liaises with partner proteins in disulfide-dependent complexes within the testis
  • induced during puberty and represents the first example of a PDI family member under developmental control
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a tissue-specific chaperone complex with the calnexin homologue calmegin (CLGN)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the oxidoreductase ERO1L, demonstrating that the N-terminal cysteine of the CXXC sequence is not required for binding of PDI family proteins to ER oxidoreductases
  • cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pdilt-/- mice were male infertile because Adam3 could not be folded properly and transported to the sperm surface without the Pdilt/Calr3 complex