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FLASH GENE
Symbol PDIA4 contributors: mct - updated : 25-07-2005
HGNC name protein disulfide isomerase family A, member 4
HGNC id 30167
Location 7q36.1      Physical location : 148.700.153 - 148.725.782
Synonym name
  • protein disulfide isomerase-associated 4
  • protein disulfide isomerase related protein (calcium-binding protein,
  • intestinal-related)
  • endoplasmic reticulum resident protein 72
  • endoplasmic reticulum resident protein 70
  • Synonym symbol(s) ERP70, ERP72
    EC.number 5.3.4.1
    DNA
    TYPE functioning gene
    STRUCTURE 25.63 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2970 - 645 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three thioredoxin domains
  • HOMOLOGY
    interspecies ortholog to murine Cai
    Homologene
    FAMILY
  • protein disulfide isomerase family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    basic FUNCTION
  • isomerase activity on S-S bonds in proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Ca2+ binding
  • protein
  • functionally associates with NOX1, regulating redox-sensitive signalling pathways in a cellular context
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS