SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,microsome
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text
| cholesterol enriched microdomains (rafts) |
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localized in the cytosol, endoplasmic reticulum (ER) and nucleus |
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mainly localized in the endoplasmic reticulum |
basic FUNCTION
| oxidoreductase that, in conjunction with calnexin and calreticulin, assists disulfide bond formation in folding glycoproteins |
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controlling the folding of proteins |
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involved in protein-nucleus import, protein-ER retention, electron transport, signal transduction |
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functioning in the endoplasmic reticulum together with the lectins calreticulin and calnexin to achieve folding of newly synthesized glycoproteins |
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may be involved in the redox regulation of components during assembly and peptide loading |
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. may be functioning as thiol-dependent oxidoreductase (Adikesavan 2008) |
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play a role in gamete fusion and regulation of transcription factors APEX1 |
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chaperone for the signal transducer and activator of transcription (STAT) signaling in which STAT3 protein function in the cytoplasm as complexes with novel accessory scaffolding protein |
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catalyze the isomerization of non-native disulfide bonds formed in glycoproteins with unstructured disulfide-rich domains (Jessop 2009) |
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participates in the nuclear import and degradation of RARA in Sertoli cells |
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may act as a molecular chaperone that alters the protein conformation of RARA for its delivery to the nucleus and, then with time, accompanies RARA to the ER for RARA ubiquitination and proteasome-mediated ERAD |
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is involved in the assembly of MTOR and positively regulates MTOR signaling at the cytosol and the cytosolic side of the ER |
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participation in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair |
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by ER luminal interaction with STIM1, has a modulatory role in capacitative Ca(2+) entry |
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forms disulfide bonds in glycoproteins in the endoplasmic reticulum and is expressed on the platelet surface |
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glycoprotein-specific PDIA3, is required for platelet aggregation, hemostasis, and thrombosis |
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of particular interest given its potential role in regulating chemosensitivity of cancer cells |
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acts in concert with calreticulin and calnexin in the folding of glycoproteins destined to the plasma membrane or to be secreted |
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participates in the regulation of calcium homeostasis, and is a potent regulator of mitochondrial calcium homeostasis |