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FLASH GENE
Symbol PDGFRL contributors: npt/ - updated : 26-02-2004
HGNC name platelet-derived growth factor receptor-like
HGNC id 8805
Location 8p22      Physical location : 17.433.941 - 17.500.642
Synonym name
  • PDGF-receptor beta-like tumor suppressor (see TSG8A)
  • platelet-derived growth factor-beta-like tumor suppressor
    • Synonym symbol(s) PRLTS, PDGRL
    DNA
    TYPE functioning gene
    STRUCTURE 65.98 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    N33 8p22 leucine zipper, putative tumor suppressor 1 LOC137012 8p22 protein phosphatase 1A pseudogene LOC392202 8 similar to 60S ribosomal protein L32 MSR1 8p22 macrophage scavenger receptor 1 LOC392203 8 similar to matricin MRPL49P2 8p22 similar to matricin FGF20 8p22-p21.3 fibroblast growth factor 20 LOC286097 8p22 hypothetical protein LOC286097 ZDHHC2 8p21.3-p22 zinc finger, DHHC domain containing 2 CNOT7 8p22-p21.3 CCR4-NOT transcription complex, subunit 7 FLJ32642 8p22 hepatocellular carcinoma related protein 1 MTMR7 8p22 myotubularin related protein 7 LOC392204 8 similar to ADAM 25 precursor (A disintegrin and metalloproteinase domain 25) (Testase 2) SLC7A2 8p22-p21.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 PDGFRL 8p22-p21.3 platelet-derived growth factor receptor-like MTSG1 8p22 mitochondrial tumor suppressor gene 1 LOC389636 8 LOC389636 FGL1 8p22-p21.3 fibrinogen-like 1 PCM1 8p22-p21.3 pericentriolar material 1 ASAH1 8p22-p21.3 N-acylsphingosine amidohydrolase (acid ceramidase) 1 MRPS18CP3 8p21.3 mitochondrial ribosomal protein S18C pseudogene 3 UNQ9391 8p23.1 tryptophan/serine protease NAT1 8p22 N-acetyltransferase 1 (arylamine N-acetyltransferase) LOC392205 8 similar to acetyltransferase LOC392206 8 similar to ribosomal protein L10a NAT2 8p22 N-acetyltransferase 2 (arylamine N-acetyltransferase) DKFZp761K1423 8p22 hypothetical protein DKFZp761K1423 EFA6R 8pter-p23.3 hypothetical protein DKFZp761K1423 LOC389637 8 LOC389637 LOC389638 8 LOC389638 LOC392207 8 similar to PMCA2av FLJ20967 8p21.2 hypothetical protein FLJ20967 ChGn 8p21.3 chondroitin beta1,4 N-acetylgalactosaminyltransferase FLJ10569 8p21.3 hypothetical protein FLJ10569 LPL 8p22 lipoprotein lipase SLC18A1 8p21.3 solute carrier family 18 (vesicular monoamine), member 1 ATP6V1B2 8p22 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 LZTS1 8p22 leucine zipper, putative tumor suppressor 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1502 - 375 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     liver   highly
    Nervousbrain    
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • N terminal signal peptide
  • immunoglobulin domain
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • CSF-1/PDGF receptor subfamily
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning as a tumor suppressor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    or mutation in sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS