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FLASH GENE
Symbol PDGFD contributors: - updated : 13-08-2007
HGNC name platelet derived growth factor D
HGNC id 30620
Location 11q22.3-q23.2      Physical location : 103.777.914 - 104.035.027
Synonym name
  • spinal cord-derived growth factor-B
  • iris-expressed growth factor
  • Synonym symbol(s) SCDGFB, IEGF, MSTP036
    DNA
    TYPE functioning gene
    STRUCTURE 257.00 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3997 42.85 370 - Hamada
  • a 7 exons variant
  • a 347 amino acids mature peptide (40.2 kDa)
  • containing exon 2a (longer than 2b)
  • encoding for the longer isoform 1
  • - splicing 3979 42.2 364 - Hamada
  • a 7 exons variant
  • a 351 amino acids mature peptide (40.6 kDa)
  • containing exon 2b (shorter than 2a)
  • encoding for the shorter isoform 2
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
     vesselsaorta  moderately
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  moderately
    Reproductivefemale systemuterus  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tracttrachea  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   moderately
    cell lineage
    cell lines adrenal cortex carcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 23 amino acids signal peptide (2.6 kDa)
  • N terminal CUB domain
  • C terminal PDGF cystine knot growth factor domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee PDGFD (100.00 pc)
    homolog to murine Pdgfd (85.14 pc)
    homolog to chicken PDGFD (81.15 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor superfamily
  • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION protease important for growth survival and fucntion in several types of connective tissue cells
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein PDGFR-beta, specifically
    cell & other
    REGULATION
    activated by limited proteolysis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS