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FLASH GENE

Symbol

PDGFD

contributors: - updated : 13-08-2007

HGNC name	platelet derived growth factor D
HGNC id	30620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.3-q23.2      Physical location : 103.777.914 - 104.035.027
Synonym name	spinal cord-derived growth factor-B
	iris-expressed growth factor
Synonym symbol(s)	SCDGFB, IEGF, MSTP036

DNA

TYPE	functioning gene
STRUCTURE	257.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3997 variant 1 42.85 370 - Hamada a 7 exons variant a 347 amino acids mature peptide (40.2 kDa) containing exon 2a (longer than 2b) encoding for the longer isoform 1 variant 2 - splicing 3979 variant 2 42.2 364 - Hamada a 7 exons variant a 351 amino acids mature peptide (40.6 kDa) containing exon 2b (shorter than 2a) encoding for the shorter isoform 2

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately   vessels aorta     moderately Endocrine adrenal gland       highly   neuroendocrine pituitary     moderately Reproductive female system uterus     moderately   male system testis     moderately Respiratory respiratory tract trachea     predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       moderately

cell lineage
cell lines	adrenal cortex carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 23 amino acids signal peptide (2.6 kDa)
	N terminal CUB domain
	C terminal PDGF cystine knot growth factor domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee PDGFD (100.00 pc)
	homolog to murine Pdgfd (85.14 pc)
	homolog to chicken PDGFD (81.15 pc)

Homologene

FAMILY

PDGF/VEGF growth factor superfamily

CATEGORY

enzyme , signaling growth factor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

protease important for growth survival and fucntion in several types of connective tissue cells

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

PDGFR-beta, specifically

cell & other

REGULATION

activated by

limited proteolysis

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS