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FLASH GENE
Symbol PDGFC contributors: mct/npt - updated : 23-02-2016
HGNC name platelet derived growth factor C
HGNC id 8801
Location 4q32.1      Physical location : 157.682.763 - 157.892.546
Synonym name
  • spinal cord derived growth factor
  • fallotein
  • secretory growth factor-like protein
  • platelet-derived growth factor C
  • Synonym symbol(s) SCDGF, FALLOTEIN, VEGF-E
    DNA
    TYPE functioning gene
    STRUCTURE 209.78 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3007 - 345 - Zhao (2008)
    regulated by PDGF-Cb,and its deregulation is involved in Renal cell carcinoma tumorigenesis
    - - - - - - Zhao (2008)
  • also called PDGF-Cb
  • encodes an N-terminally truncated protein, lacking the signal peptide and CUB domain
  • produced as a cytoplasmic protein, and has a similar intracellular localization to PDGFC, but is not secreted from transfected cells
  • can form heterodimers (PDGF-CCb) with PDGFC
  • might act as a dominant negative molecule regulating the secretion of PDGFC
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestivemouth   moderately
     pharynx   moderately
    Endocrineparathyroid   predominantly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systemuterus  moderately
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidneynephron  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularsmooth  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal CUB domain
  • a core motif of eight cysteines
  • C terminal PDGF cystine knot growth factor
  • HOMOLOGY
    interspecies homolog to rattus Pdgfc (85.80 pc)
    homolog to murine Pdgfc (86.96 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • required in palate formation
  • growth factor regulating fibrogenic/fibrolytic genes in dermal fibroblasts
  • mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment (Crawford 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FREM1 binds to PDGFC and this interaction regulates signalling downstream of PDGFRA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in podocytes and in interstitial cells after injury/activation of these cells
    tumoral     --over  
    increased in Renal cell carcinomas (Choi 2009)
    Susceptibility to cleft lip/palate
    Variant & Polymorphism SNP -986T allele is associated with a significant decrease (up to 80p100) of PDGFC gene promoter activity and to to cleft lip/palate (Choi 2009)
    Candidate gene for malignant pleural mesothelioma
    Marker
    Therapy target
    ANIMAL & CELL MODELS