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FLASH GENE
Symbol PDF contributors: mct - updated : 16-03-2016
HGNC name peptide deformylase (mitochondrial)
HGNC id 30012
Location 16q22.1      Physical location : 69.362.523 - 69.364.498
Synonym name
  • peptide deformylase-like protein
  • polypeptide deformylase
    • Synonym symbol(s) PDFM, HsPDF
    EC.number 3.5.1.88
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text overlap between the COG8 and PDF was initiated by the gain of a novel splice donor site between the COG8 stop codon and PDF initiation codon
    STRUCTURE 1.97 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • several transcription start sites, the most important of which only 18 bp from the initiation codon
  • a 97 bp minimal promoter region capable of very strong transcriptional activity; this fragment contains a potential Sp1 binding site highly conserved in mammalian species
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1180 - 243 - 2009 19236878
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • role in mitochondrial protein deformylation and in the maintenance of the oxydative phosphorylation complexes integrity
  • participate in the N-terminal methionine excision pathway of newly synthesized peptides
  • can deformylate its putative substrates derived from mitochondrial DNA-encoded proteins
  • essential role for PDF in eukaryotic protein processing
  • appears to have a role in maintenance of mitochondrial respiratory function, and this function is analogous to that of chloroplast PDF
  • having a function in the mitochondria and a role in mtDNA-encoded protein-containing oxidative phosphorylation (OXPHOS) complex biogenesis
  • removes the formyl group at the N-terminal methionine residue of nascent protein
  • is essential in post-translational modification of mitochondrial-encoded proteins
  • PDF uses a short promoter that does not include COG8 coding sequences and, in that sense, the expression of the PDF gene is independent of its overlapping partner
  • may act as an oncogene to promote cancer cell proliferation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYC regulated the expression of PDF, likely indirectly
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    PDF inhibition results in survival based on the capacity of the cell to carry out aerobic glycolysis
    tumoral     --over  
    in cancer cells and primary acute myeloid leukemia samples
    tumoral     --over  
    in breast, colon, and lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    potent target for antibacterial therapy
    immunologyinfectious 
    emerging therapeutic target for the treatment of tuberculosis and peptide deformylase inhibitors can act as potential future antibacterial agents.
    cancer  
    cancer target
    cancerhemopathy 
    may be a therapeutic target for the hematopoietic cancers
    ANIMAL & CELL MODELS