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FLASH GENE
Symbol PDE8A contributors: mct - updated : 18-12-2018
HGNC name phosphodiesterase 8A
HGNC id 8793
Location 15q25.3      Physical location : 85.525.204 - 85.682.370
Synonym name
  • high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  • Synonym symbol(s) HsT19550, FLJ16150
    EC.number 3.1.4.17/3.1.4.53
    DNA
    TYPE functioning gene
    STRUCTURE 158.63 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 splicing 3931 - 829 - 2001 11738832
    lacking the PAS domain
    21 splicing 3793 - 783 - 2001 11738832
    22 splicing 3728 - 757 - 2001 11738832
    - splicing - - 582 - 2001 11738832
    half of the PAS domain
    - splicing - - 582 - 2001 11738832
    half of the PAS domain
    - splicing - - 449 - 2001 11738832
    lacking te PAS and the REC domains
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  specific Homo sapiens
     male systemtestis  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Reproductivegranulosa cell Homo sapiens
    ReproductiveLeydig cell Homo sapiens
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • N terminal REC domain
  • a PAS domain
  • a C catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text
  • largely associated with mitochondria
  • basic FUNCTION
  • may would be involved in signal transduction
  • is a novel cardiac phosphodiesterases that controls one or more pools of cAMP implicated in regulation of Ca(2+) movement through cardiomyocyte
  • potential role for PDE8A in cAMP signaling related to pain transmission, motor function, cognition and olfaction
  • PDE8A supports HIV-1 replication in macrophages and that this effect is mediated at the level of reverse transcription
  • cyclic nucleotide PDEs play important role in the achievement of meiotic competency by reducing intraoocyte cyclic nucleotides level in mammalian oocytes
  • regulates T cell motility
  • exerts part of its control of T cell function through RAF1 kinase signaling pathway
  • controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping cholesterol-ester hydrolase (CEH)/hormone-sensitive lipase (HSL) inactive and STAR protein expression low
  • PDE8A is a physiological regulator of RAF1 signaling in some cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS