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FLASH GENE
Symbol PDE7A contributors: - updated : 21-05-2005
HGNC name phosphodiesterase 7A
HGNC id 8791
Location 8q13      Physical location : 66.629.905 - 66.753.755
Synonym symbol(s) HCP1, PDE7
EC.number 3.1.4.1
DNA
TYPE functioning gene
STRUCTURE 124.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site
text structure
  • 5'-flanking region containing CpG islands
  • three potential CREB-binding sites
  • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3979 57 482 several T-and B cell lines Han, Torras-Llort
    required for T-cell activation
    - splicing 1739 50 456 restricted to skeletal muscle, heart Han, Torras-Llort
    starting at exon 2 which is spliced
    - - 2990 - 424 - Glavas
    up-regulated upon T-cell activation
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • cAMP specific nucleotide phosphodiesterase class VII,A, high affinity
  • may regulate T cell function including cytokine production, proliferation and expression of activation markers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS