basic FUNCTION
| cGMP specific nucleotide phosphodiesterase, class VI, delta subunit |
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putatively involved in the control of the dynamic of RAB13 association with cellular membranes |
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functions as a prenyl-binding protein interacting with multiple prenylated proteins |
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role in the transport of prenylated proteins from their site of synthesis in the inner segment to the outer segment where phototransduction occurs |
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functional role of PDE6D in alveolar epithelial cells proliferation |
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its activity augments K/HRAS signalling by enriching RAS at the plasma membrane, and conversely, its down-modulation randomizes RAS distributions to all membranes in the cell |
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its activity is linked in determining RAS protein topography to RAS-dependent signalling |
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is required for INPP5E ciliary targeting, suggesting a broader role for PDE6D in targeting other prenylated proteins to the cilia |