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FLASH GENE

Symbol

PDE4C

contributors: mct - updated : 21-03-3015

HGNC name	phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
HGNC id	8782

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.11      Physical location : 18.318.771 - 18.359.010
Synonym symbol(s)	DPDE1, PDE4C-791
EC.number	3.1.4.17

DNA

TYPE	functioning gene
STRUCTURE	40.24 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	two consensus HNF1B binding sites in the PDE4C promoter located 582 and
	860 bp upstream from the translation start site
	DNA methylation levels at several individual age-associated CpGs seem to be associated with life expectancy - e.g., at CpGs associated with the genes PDE4C and CLCN6

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000923 16 - 6346 NP_000914 - 712 - 2010 20701803 PDE4C1 NM_001098818 15 - 5034 NP_001092288 - 680 - 2010 20701803 PDE4C3 NM_001098819 15 - 5124 NP_001092289 - 606 - 2010 20701803 PDE4C2

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Reproductive female system ovary       Respiratory respiratory tract larynx       Urinary kidney         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to Drosophila dunce gene

Homologene

FAMILY

cyclic nucleotide phosphodiesterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	cAMP specific nucleotide phosphodiesterase class IV, C
	promotes the hydrolysis of cAMP, and PKD2, functioning
	as a Ca2+ entry channel, may mediate local accumulation of Ca2+ that inhibits the activity of Ca2+-sensitive ADCY5

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

PKD2 and PDE4C are unique components of an AKAP complex in primary cilia

INTERACTION

DNA

RNA

small molecule

protein	interacts with the AKAP5 complex
	potential HNF1B target gene (HNF1B directly regulates
	PDE4C gene transcription)

cell & other

REGULATION

inhibited by

rolipram

Other

its expression is regulated by the transcription factor hepatocyte nuclear factor-1beta (HNF1B)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS