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FLASH GENE
Symbol PDE3B contributors: mct - updated : 07-02-2018
HGNC name phosphodiesterase 3B, cGMP-inhibited
HGNC id 8779
Location 11p15.2      Physical location : 14.665.268 - 14.893.602
Synonym symbol(s) HCG1P1, CN3B, cGIPDE1
EC.number 3.1.4.35/3.1.4.17
DNA
TYPE functioning gene
STRUCTURE 228.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 5400 - - adipose tissues Kasuya
16 - 6091 - 1112 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Endocrineneuroendocrinepituitary  highly Homo sapiens
 pancreas   highly Homo sapiens
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
 adipocyte Homo sapiens
Digestivehepatocyte Homo sapiens
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminus required for the efficient targeting to and association with RE
HOMOLOGY
interspecies homolog to murine pde3b
Homologene
FAMILY cyclic nucleotide phosphodiesterase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • may play a role in fat metabolism
  • PDE3B is involved in the regulation of nutrient-stimulated insulin secretion
  • through hydrolysis of cAMP in pools regulated by Ca(2+), plays a regulatory role in depolarization-induced insulin secretion and the enzyme is associated with the exocytotic machinery in beta-cells
  • PDE3B pathway plays an important role in mediating LEP action in the hypothalamus
  • PDE3B has an important role in the regulation of insulin secretion in pancreatic beta-cells
  • direct role of the PDE3B pathway in mediating LEP signaling in the POMC and NPY neurons-a potential mechanism of leptin signaling in the hypothalamus
  • mediates insulin action in the adipose tissue
  • activation of PDE3B is likely a novel mechanism of insulin signaling in the hypothalamus
  • enzyme that catalyzes hydrolysis of cAMP and cGMP, and is highly expressed in tissues that regulate energy homeostasis
  • PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LEP stimulates phosphodiesterase-3B (PDE3B) activity in the hypothalamus, and PDE3 inhibitor cilostamide reverses anorectic and bodyweight reducing effects of leptin
  • PDE3B links insulin- and cAMP-signaling networks in tissues associated with energy metabolism, including white adipose tissue (WAT)
  • CELF1 is a critical regulator of insulin secretion via activating PDE3B
  • cell & other
    REGULATION
    inhibited by cAMP,cGMP
    Phosphorylated by AKT1, but phosphorylation of PDE3B by AKT1 is not required for insulin to suppress adipocyte lipolysis
    Other is activated in response to agents relevant for &
    946;beta-cell function and activation is linked to increased as well as decreased phosphorylation of the enzyme
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders
    obesity  
    potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders
    ANIMAL & CELL MODELS