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FLASH GENE
Symbol PDE3B contributors: mct - updated : 07-02-2018
HGNC name phosphodiesterase 3B, cGMP-inhibited
HGNC id 8779
Location 11p15.2      Physical location : 14.665.268 - 14.893.602
Synonym symbol(s) HCG1P1, CN3B, cGIPDE1
EC.number 3.1.4.35/3.1.4.17
DNA
TYPE functioning gene
STRUCTURE 228.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
USP47 11p15.2 ubiquitin specific protease 47 RIG 11p15.1 ubiquitin specific protease 47 DKK3 11p15.2 dickkopf homolog 3 (Xenopus laevis) MICAL2 11p15.2 dickkopf homolog 3 (Xenopus laevis) FLJ14966 11p15.3 hypothetical protein FLJ14966 PARVA 11p15.2 parvin, alpha TEAD1 11p15.2 TEA domain family member 1 (SV40 transcriptional enhancer factor) LOC119593 11p15.3 similar to RIKEN cDNA 4632411J06 ARNTL 11p15 aryl hydrocarbon receptor nuclear translocator-like GMRP-1 11p15.3-p15.2 K+ channel tetramerization protein PTH 11p15.2-p15.1 parathyroid hormone FLJ22728 11p15.2 hypothetical protein FLJ22728 LOC338750 11p15.2 similar to hypothetical protein FLJ33167 LOC387754 11 LOC387754 SPON1 11p15.2-p14 spondin 1, (f-spondin) extracellular matrix protein RRAS2 11p15.2 related RAS viral (r-ras) oncogene homolog 2 LOC390094 11 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein COPB 11p15.4-p15.2 coatomer protein complex, subunit beta PSMA1 11p15.1 proteasome (prosome, macropain) subunit, alpha type, 1 PDE3B 11p15.1 phosphodiesterase 3B, cGMP-inhibited MORF4LP3 11p mortality factor 4 like pseudogene 3 CYP2R1 11p15.2 cytochrome P450, family 2, R1 CALCP 11p15.2-p15.1 calcitonin pseudogene CALCA 11p15.2-p15.1 calcitonin/calcitonin-related polypeptide, alpha OR7E41P 11p15 olfactory receptor, family 7, subfamily E, member 41 pseudogene CALCB 11p15.2-p15.1 calcitonin-related polypeptide, beta LOC387755 11 similar to RIKEN cDNA 3830422K02 LOC387756 11 LOC387756 SOX6 11p15.3 SRY (sex determining region Y)-box 6 LOC390095 11 similar to Aldose reductase (AR) (Aldehyde reductase) SMAP 11p15.2 small acidic protein LOC283278 11p15.2 hypothetical protein LOC283278 LOC144100 11p15.2-p15.1 hypothetical protein LOC144100 LOC390096 11 similar to large subunit ribosomal protein L36a OR7E14P 11p15.1 olfactory receptor, family 7, subfamily E, member 14 pseudogene RPS13 11p15.1 ribosomal protein S13 PIK3C2A 11p15.1 phosphoinositide-3-kinase, class 2, alpha polypeptide LOC91561 11p15.1 similar to ribosomal protein S2; 40S ribosomal protein S2 NUCB2 11p15.1-p14 nucleobindin 2 DKFZp686O24166 11p15.1 hypothetical protein DKFZp686O24166 KCNJ11 11p15.1 potassium inwardly-rectifying channel, subfamily J, member 11 ABCC8 11p15.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 5400 - - adipose tissues Kasuya
16 - 6091 - 1112 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Endocrineneuroendocrinepituitary  highly Homo sapiens
 pancreas   highly Homo sapiens
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
 adipocyte Homo sapiens
Digestivehepatocyte Homo sapiens
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminus required for the efficient targeting to and association with RE
HOMOLOGY
interspecies homolog to murine pde3b
Homologene
FAMILY cyclic nucleotide phosphodiesterase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • may play a role in fat metabolism
  • PDE3B is involved in the regulation of nutrient-stimulated insulin secretion
  • through hydrolysis of cAMP in pools regulated by Ca(2+), plays a regulatory role in depolarization-induced insulin secretion and the enzyme is associated with the exocytotic machinery in beta-cells
  • PDE3B pathway plays an important role in mediating LEP action in the hypothalamus
  • PDE3B has an important role in the regulation of insulin secretion in pancreatic beta-cells
  • direct role of the PDE3B pathway in mediating LEP signaling in the POMC and NPY neurons-a potential mechanism of leptin signaling in the hypothalamus
  • mediates insulin action in the adipose tissue
  • activation of PDE3B is likely a novel mechanism of insulin signaling in the hypothalamus
  • enzyme that catalyzes hydrolysis of cAMP and cGMP, and is highly expressed in tissues that regulate energy homeostasis
  • PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LEP stimulates phosphodiesterase-3B (PDE3B) activity in the hypothalamus, and PDE3 inhibitor cilostamide reverses anorectic and bodyweight reducing effects of leptin
  • PDE3B links insulin- and cAMP-signaling networks in tissues associated with energy metabolism, including white adipose tissue (WAT)
  • CELF1 is a critical regulator of insulin secretion via activating PDE3B
  • cell & other
    REGULATION
    inhibited by cAMP,cGMP
    Phosphorylated by AKT1, but phosphorylation of PDE3B by AKT1 is not required for insulin to suppress adipocyte lipolysis
    Other is activated in response to agents relevant for &
    946;beta-cell function and activation is linked to increased as well as decreased phosphorylation of the enzyme
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders
    obesity  
    potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders
    ANIMAL & CELL MODELS