SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
basic FUNCTION
| may play a role in fat metabolism |
|
PDE3B is involved in the regulation of nutrient-stimulated insulin secretion |
|
through hydrolysis of cAMP in pools regulated by Ca(2+), plays a regulatory role in depolarization-induced insulin secretion and the enzyme is associated with the exocytotic machinery in beta-cells |
|
PDE3B pathway plays an important role in mediating LEP action in the hypothalamus |
|
PDE3B has an important role in the regulation of insulin secretion in pancreatic beta-cells |
|
direct role of the PDE3B pathway in mediating LEP signaling in the POMC and NPY neurons-a potential mechanism of leptin signaling in the hypothalamus |
|
mediates insulin action in the adipose tissue |
|
activation of PDE3B is likely a novel mechanism of insulin signaling in the hypothalamus |
|
enzyme that catalyzes hydrolysis of cAMP and cGMP, and is highly expressed in tissues that regulate energy homeostasis |
|
PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue |