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FLASH GENE
Symbol PDE1B contributors: mct/npt - updated : 30-06-2008
HGNC name phosphodiesterase 1B, calmodulin-dependent
HGNC id 8775
Location 12q13      Physical location : 54.943.176 - 54.973.023
Synonym name
  • calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
  • calmodulin-stimulated phosphodiesterase PDE1B1
  • phosphodiesterase IB,3',5' cyclic nucleotide
  • Cam-PDE 1B
  • Synonym symbol(s) PDE1B1, PDES1B, PDE1B2
    EC.number 3.1.4.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, head to head
    STRUCTURE 29.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D12S325 - D12S1707 - PDE1B - ITGA5 - ITGA7 - CDK2 - ERBB3 - GLI - D12S1691 - qter
    Authors Gene Map
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3236 61.4 536 - Bender (2006)
    - - 2985 - 516 - Bender (2005), Fidock (2002)
  • selectively increased by GM-CSF by stimulation of transcription at a previously unknown transcriptional start site
  • has a different N-terminal sequence because of a separate first exon that is located 11.5 kb downstream from the PDE1B1 first exon
  • diverges from PDE1B1 by the replacement of the first 38 residues by an alternative 18, which is predicted to be functionally significant
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum  
     braindiencephalonhypothalamus  
     brainbasal nucleicaudate nucleus  
     brain   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines leukemic cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulates cGMP and plays a lesser role in cAMP regulation in response to cyclase agonists
  • plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels
  • may have a regulatory role in multiple immune cell types
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS