protein
| binds to endophilins and induces cytoplasmic vacuolization |
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regulates cell death in a way involving interactions with the calcium-binding protein PDCD6 and with proteins of ESCRT (endosomal sorting complex required for transport) |
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binds to HIV-1 p6 and is incorporated in HIV-1 virions |
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target protein for PDCD6, participating in multiple functions, including apoptosis, endocytic membrane trafficking, and cytoskeletal remodeling |
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interacts with a series of different proteins, including CEP55, CD2AP, with three other proteins involved in cytokinesis, ROCK1, and IQGAP, and viral late domains of the YPXL class |
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interacting with TSG101 and PDCD6 (Ca2+-loaded PDCD6 bridges PDCD6IP and TSG101 as an adaptor protein) |
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associate with F-actin in epithelial cells and fibroblasts, where it participates in the organization of actin fibers |
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HCK (haemopoietic cell kinase) SH3 domain interactor( |
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crucial mediator of Ca(2+) induced caspase 9 activation |
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PDCD6 and PDCD6IP cooperate in transducing Ca2+-regulated signals during cell death |
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is a novel HCK (haemopoietic cell kinase) SH3 domain interactor |
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directly interacts with alpha-actinin and promotes its association with F-actin in fibroblast |
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PDCD6IP is a bona fide interacting partner of NEURL2 and interaction between the two native proteins occurs in the differentiated muscle fibers |
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SDCBP interacts directly with PDCD6IP through LYPX(n)L motifs, similarly to retroviral proteins |
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PDCD6IP binds to F2R, recruits ESCRT-III, and mediates receptor sorting to intraluminal vesicles (ILVs) of multivesicular bodies (MVBs)/lysosomes |
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AP3B1 facilitates F2R interaction with PDCD6IP, suggesting that AP3B1 functions before F2R engagement of PDCD6IP and multivesicular bodies (MVBs)/lysosomes sorting |
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important role for K63 polyUb binding by PDCD6 in retroviral release |
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TEX14 competitively binds to CEP55-EABR to prevent the recruitment of PDCD6IP, which is a component of the ESCRT machinery with the AxGPPx3Y motif |
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in contrast to CHMP4B, recruitment of CHMP4C relies predominantly on PDCD6IP |
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PDCD6IP promotes Microtubule (MT) stability by recruiting microtubule-associated protein 1S (MAP1S), which stabilizes newly formed MTs |