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FLASH GENE
Symbol PDCD6 contributors: mct - updated : 02-04-2015
HGNC name programmed cell death 6
HGNC id 8765
Location 5p15.33      Physical location : 271.735 - 315.089
Synonym name
  • apoptosis linked gene 2
  • calcium-binding protein
  • Synonym symbol(s) ALG2, ALG-2, MGC111017, MGC119050, MGC9123, PEF1B, FLJ46208
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, head to head
    STRUCTURE 43.35 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1151 - 191 - 2009 19520058
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Endocrinepancreas   moderately
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
    Respiratorylung   moderately
     respiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five canonical Ca2+ binding EF hand structures, the PEF (penta-EF-hand) domain
  • HOMOLOGY
    interspecies murine Pdcd6
    Homologene
    FAMILY
  • penta EF-hand protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text distributed in a punctate pattern in the cytoplasm, where it was partly co-stained with an endoplasmic reticulum (ER) exit site marker p125
    basic FUNCTION
  • required for T cell receptor-Fas-glucocorticoid-induced cell death
  • penta-EF-hand protein, playing a necessary role for caspase activation following an abnormal rise in cytosolic calcium
  • may allow the recruitment of pro-caspase-8 onto endosomes containing TNFRSF1A, a step thought to be necessary for activation of the apical caspase
  • Ca2+- loaded PDCD6 bridges PDCD6IP and TSG101 as an adaptor protein
  • acts as a Ca2+ sensor that modulates the function of MCOLN1 along the late endosomal-lysosomal pathway
  • directly binds to the amino-terminal cytosolic tail of MCOLN1, thus regulating MCOLN1 function at the endosomal/lysosomal pathway
  • is involved in cell death, signal transduction, membrane trafficking, etc., by interacting with various proteins in mammalian cells in a Ca2+-dependent manner
  • recognizes two types of motifs at different hydrophobic surfaces
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with PEF1
  • can also form a complex with pro-caspase-8, independently of PDCD6IP, and that this requires the prodomain of the zymogen but not the catalytic activity of the protease
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • PEF
  • directly binds SEC31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner
  • (functions as a Ca2+ sensor in the redistribution of SEC31A)
  • RBM22 which can shuttle between the cytoplasm and the nucleus may play a role in nuclear translocation of PDCD6
  • functional interaction between the Ca(2+)-signaling protein PDCD6 and the RNA-binding protein RBM22
  • interacting with PDCD6IP
  • interacts with various intracellular proteins, such as PDCD6IP and TSG101
  • PDCD6 and PDCD6IP cooperate in transducing Ca2+-regulated signals during cell death
  • is interacting with RBM22, a highly conserved spliceosomal nuclear protein
  • binding of PDCD6 to SEC31A and inhibition of COPII vesicle budding is furthermore dependent on an intact Ca(2+)-binding site at EF-hand 1 of PDCD6
  • ANXA11, physically associates with SEC31A by the adaptor function of PDCD6
  • interacts with the ER-localized scotin (SHISA5) protein which is a proapoptotic-TP53-inducible protein
  • PDCD6/SEC31A interactions were not required for the localization of SEC31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
  • binding with SEC31A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS