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FLASH GENE
Symbol PDCD2L contributors: mct - updated : 06-12-2023
HGNC name programmed cell death 2-like
HGNC id 28194
Location 19q13.11      Physical location : 34.895.302 - 34.917.070
Synonym symbol(s) MGC13096
DNA
TYPE functioning gene
STRUCTURE 21.77 kb     7 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1157
7 - 1151 - 356 - 2016 27697862
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Lymphoid/Immunetonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
PDCD2(C) domain
HOMOLOGY
intraspecies paralog to PDCD2
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
text
  • PDCD2L shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner using a leucine-rich nuclear export signal that is sufficient to direct the export of a reporter protein
  • basic FUNCTION
  • involved in apoptosis
  • PDCD2L and its paralog, PDCD2, function redundantly in 40S ribosomal subunit production
  • evolutionarily conserved role of PDCD2L in development
  • is a shuttle protein of the nucleus and cytoplasm and is related to the ribosome biogenesis
  • PDCD2L has a regulatory effect on inflammation and oxidative stress of vascular endothelial cells
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RPS2 promotes likely the formation of a conserved extraribosomal complex with PRMT3 and PDCD2L
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCD2Lis a novel PRMT3-associated protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    PDCD2L is a potential anti-inflammatory therapeutic target
    ANIMAL & CELL MODELS