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FLASH GENE
Symbol PDCD10 contributors: mct/npt/pgu - updated : 28-11-2015
HGNC name programmed cell death 10
HGNC id 8761
Corresponding disease
CCM3 cerebral cavernous malformation 3
Location 3q26.1      Physical location : 167.401.696 - 167.452.651
Synonym name
  • apoptosis-related protein 15
  • TF-1 cell apoptosis-related protein 15
  • cerebral cavernous malformation 3
  • Synonym symbol(s) TFAR15, MGC1212, MGC24477, CCM3
    DNA
    TYPE functioning gene
    STRUCTURE 50.96 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BCHE 3q26.1-q26.2 butyrylcholinesterase LOC389173 3 similar to phosphoserine aminotransferase isoform 1 LOC285320 3q26.2 similar to heterochromatin-specific nonhistone protein LOC131055 3q26.2 similar to peptidyl-Pro cis trans isomerase FLJ23049 3q26.2 hypothetical protein FLJ23049 SERPINI2 3q26.1-q26.2 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2 FLJ33620 3q26.2 hypothetical protein FLJ33620 PDCD10 3q26.2 programmed cell death 10 SERPINI1 3q26.31 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 GOLPH4 3q26 Golgi phosphoprotein 4 LOC389174 3 LOC389174 LOC253820 3q26.2-q26.31 similar to MEGF6 LOC93556 3q26.31 hypothetical protein BC011266 EVI1 3q26 ecotropic viral integration site 1 MDS1 3q21-q26 myelodysplasia syndrome 1 LOC389175 3 similar to ribosomal protein L22 LOC285262 3q26.31 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat TERC 3q26 telomerase RNA component ARPM1 3q26.31 actin related protein M1 MYNN 3p21.3-q25.2 myoneurin MGC27085 3q26.31 hypothetical protein MGC27085 LOC344657 3q26.31 similar to RIKEN cDNA 4930558O21 FLJ23259 3q26.31 hypothetical protein FLJ23259 LOC151825 3q26.31 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SAMD7 3q26.31 sterile alpha motif domain containing 7
    RNA
    TRANSCRIPTS type messenger
    text these variants encoding the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1454 24 212 - 2009 19246713
    9 - 1313 24.7 212 - 2009 19246713
    - - 1212 24 212 - 2009 19246713
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselartery  highly
    Digestivemouth   highly
     salivary gland   highly
    Reproductivemale systemtestis    Homo sapiens
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text in the vascular endothelium during early pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FAT domain, for interacting with STRN3
  • HOMOLOGY
    interspecies ortholog to murine Pdcd10
    Homologene
    FAMILY
  • PDCD10 family
  • CCM (cerebral cavernous malformation) family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • expressed in the neurovascular unit and in the arterial endothelium of structures within multiple organ systems, including the brain
  • basic FUNCTION
  • may be participating to apoptosis
  • involved in vessel development and/or maturation
  • involved in modulation of ERK signaling mediated by MST4, and could be a regulatory adaptor necessary for MST4 function
  • having both necessary and sufficient role to induce apoptosis
  • identified in the vascular endothelium of placenta, suggesting that they might play roles during angiogenesis and vasculogenesis
  • novel function for PDCD10/CCM3, acting as a critical regulator of neuronal survival during development
  • important function of PDCD10/CCM3 in the regulation of apoptosis during vertebrate neural development
  • key component in PCDH-gamma-mediated regulation of neuronal survival
  • key regulator of neuronal survival in the PCDH-gamma pathway during development
  • has both neural cell autonomous and nonautonomous functions
  • can participate in a protein complex also containing KRIT1 and CCM2
  • required for normal physiologic function in nonvascular cells and implicate a cell nonautonomous mechanism in disease pathogenesis
  • PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
  • able to bridge interactions between the GCKIII protein MST4 and STRN3
  • PDCD10 and striatin exhibit opposing roles on the localization of the kinase MST4 to the Golgi, with striatins favoring a Golgi localization and PDCD10 promoting cytosolic location
  • might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression
  • crucial role in vascular development and in regulation of angiogenesis and apoptosis
  • KRIT1, PDCD10, and CCM2 are critical regulators of endothelial cell-cell contact and vascular homeostasis
  • PDCD10 expression in the absence of CCM2 is sufficient to support normal cell growth, revealing complex-independent roles for PDCD10
  • both CCM2 and PDCD10 are required for normal endothelial cell network formation
  • CCM2 and PDCD10 genes could likely play a role in the regulation of mouse gonadogenesis translational activation upon testicular and ovarian development
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
  • can heterodimerize with GCKIII kinases (STK24, MST4, and STK25) to regulate cardiovascular development
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MST4, a member of Ste20-related kinases (coactivation of PDCD10 and MST4 promoted cell proliferation and transformation via modulation of the extracellular signal-regulated kinase (ERK) pathway)
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
  • interaction between PDCD10 and STRIPAK via direct association with striatin may serve as a regulatory mechanism to control the function of the MST4 kinase
  • interacts with STK25, an oxidant stress response kinase related to sterile-20 (Ste20) that is activated by oxidative stress and induces apoptotic cell death
  • DLL4 is a key downstream target of PDCD10 in endothelial cells(CCM3/DLL4-Notch pathway serves as an important signalling for endothelial angiogenesis)
  • STK26 and STK25 belong to the Ste20-like kinases and interact with PDCD10 which is closely linked to cancer diseases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CCM3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS