Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PDCD10

contributors: mct/npt/pgu - updated : 28-11-2015

HGNC name	programmed cell death 10
HGNC id	8761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CCM3 cerebral cavernous malformation 3
Location	3q26.1      Physical location : 167.401.696 - 167.452.651
Synonym name	apoptosis-related protein 15
	TF-1 cell apoptosis-related protein 15
	cerebral cavernous malformation 3
Synonym symbol(s)	TFAR15, MGC1212, MGC24477, CCM3

DNA

TYPE	functioning gene
STRUCTURE	50.96 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	these variants encoding the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007217 9 - 1454 NP_009148 24 212 - 2009 19246713 NM_145859 9 - 1313 NP_665858 24.7 212 - 2009 19246713 NM_145860 - - 1212 NP_665859 24 212 - 2009 19246713

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel artery     highly Digestive mouth       highly   salivary gland       highly Reproductive male system testis       Homo sapiens Respiratory lung         Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining endometrium

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Reproductive Sertoli cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	in the vascular endothelium during early pregnancy

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a FAT domain, for interacting with STRN3

HOMOLOGY

interspecies

ortholog to murine Pdcd10

Homologene

FAMILY	PDCD10 family
	CCM (cerebral cavernous malformation) family of proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	expressed in the neurovascular unit and in the arterial endothelium of structures within multiple organ systems, including the brain

basic FUNCTION	may be participating to apoptosis
	involved in vessel development and/or maturation
	involved in modulation of ERK signaling mediated by MST4, and could be a regulatory adaptor necessary for MST4 function
	having both necessary and sufficient role to induce apoptosis
	identified in the vascular endothelium of placenta, suggesting that they might play roles during angiogenesis and vasculogenesis
	novel function for PDCD10/CCM3, acting as a critical regulator of neuronal survival during development
	important function of PDCD10/CCM3 in the regulation of apoptosis during vertebrate neural development
	key component in PCDH-gamma-mediated regulation of neuronal survival
	key regulator of neuronal survival in the PCDH-gamma pathway during development
	has both neural cell autonomous and nonautonomous functions
	can participate in a protein complex also containing KRIT1 and CCM2
	required for normal physiologic function in nonvascular cells and implicate a cell nonautonomous mechanism in disease pathogenesis
	PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
	able to bridge interactions between the GCKIII protein MST4 and STRN3
	PDCD10 and striatin exhibit opposing roles on the localization of the kinase MST4 to the Golgi, with striatins favoring a Golgi localization and PDCD10 promoting cytosolic location
	might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression
	crucial role in vascular development and in regulation of angiogenesis and apoptosis
	KRIT1, PDCD10, and CCM2 are critical regulators of endothelial cell-cell contact and vascular homeostasis
	PDCD10 expression in the absence of CCM2 is sufficient to support normal cell growth, revealing complex-independent roles for PDCD10
	both CCM2 and PDCD10 are required for normal endothelial cell network formation
	CCM2 and PDCD10 genes could likely play a role in the regulation of mouse gonadogenesis translational activation upon testicular and ovarian development

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
	can heterodimerize with GCKIII kinases (STK24, MST4, and STK25) to regulate cardiovascular development

INTERACTION

DNA

RNA

small molecule

protein	interacts with MST4, a member of Ste20-related kinases (coactivation of PDCD10 and MST4 promoted cell proliferation and transformation via modulation of the extracellular signal-regulated kinase (ERK) pathway)
	STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
	interaction between PDCD10 and STRIPAK via direct association with striatin may serve as a regulatory mechanism to control the function of the MST4 kinase
	interacts with STK25, an oxidant stress response kinase related to sterile-20 (Ste20) that is activated by oxidative stress and induces apoptotic cell death
	DLL4 is a key downstream target of PDCD10 in endothelial cells(CCM3/DLL4-Notch pathway serves as an important signalling for endothelial angiogenesis)
	STK26 and STK25 belong to the Ste20-like kinases and interact with PDCD10 which is closely linked to cancer diseases

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CCM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS