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FLASH GENE
Symbol PDC contributors: mct - updated : 10-12-2014
HGNC name phosducin
HGNC id 8759
Location 1q25.2      Physical location : 186.412.718 - 186.430.239
Synonym name
  • 33kDA phototransducing protein
  • G beta gamma binding protein
  • phosducin-like orphan protein
  • Synonym symbol(s) MEKA, PHD, PhLOP, PhLP
    DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    RGS16 1q25-q31 regulator of G-protein signalling 16 RGS8 1q25-q31 regulator of G-protein signalling 8 NPL 1q25 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) DHX9 1q25 DEAH (Asp-Glu-Ala-His) box polypeptide 9 C1orf14 1q25-q31 chromosome 1 open reading frame 14 LOC391143 1 similar to natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocyte antigen 94 (mouse) homolog (activating NK-receptor ; NK-p46); lymphocyte antigen 94 homolog, a LOC343326 1q25.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LAMC1 1q31 laminin, gamma 1 (formerly LAMB2) LAMC2 1q25-q31 laminin, gamma 2 NMNAT2 1q25-q31 nicotinamide nucleotide adenylyltransferase 2 C1orf16 1q25-q31 chromosome 1 open reading frame 16 NCF2 1q25 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) ARPC5 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa RGL 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa C1orf17 1q25-q31 chromosome 1 open reading frame 17 C1orf19 1q25-q31 chromosome 1 open reading frame 19 LOC391144 1 similar to Rho-GTPase-activating protein 8 C1orf21 1q25-q31 chromosome 1 open reading frame 21 C1orf22 1q24-q25 chromosome 1 open reading frame 22 C1orf24 1q25-q31 chromosome 1 open reading frame 24 RNF2 1q25.1 ring finger protein 2 C1orf25 1q25.2 chromosome 1 open reading frame 25 C1orf26 1q25 chromosome 1 open reading frame 26 IVNS1ABP 1q25.1-q31.1 influenza virus NS1A binding protein FIBL-6 1q25.3 hemicentin PRG4 1q25-q31 proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) TPR 1q25 translocated promoter region (to activated MET oncogene) C1orf27 1q25-q31 translocated promoter region (to activated MET oncogene) PDC 1q32-q41 phosducin LOC391145 1 similar to KIAA1871 protein PTGS2 1q25.2-q25.3 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PLA2G4A 1q25 phospholipase A2, group IVA (cytosolic, calcium-dependent) LOC343332 1q25.3 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) DBCCR1L 1q25.3 DBCCR1-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1258 28.2 246 - Nishigushi
    - splicing 1221 - 194 - Nishigushi
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepineal    
    Visualeyeretina  predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisual  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phosducin domain
  • HOMOLOGY
    interspecies ortholog to murine Pdc (86 pc)
    Homologene
    FAMILY phosducin family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • (transducin) inhibitor protein, participating in the regulation of visual phototransduction or in the integration of photoreceptor metabolism
  • previously unrecognized target of SUMO modification and SUMOylation controls phosducin stability in cells as well as its functional properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated at the posttranslational level by modification with the small ubiquitin-related modifier, SUMO
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS