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FLASH GENE
Symbol PCYT1B contributors: - updated : 22-04-2005
HGNC name phosphate cytidylyltransferase 1, choline, beta isoform
HGNC id 8755
Location Xp22.12      Physical location : 24.576.204 - 24.690.979
Synonym name phosphocholine cytidyltransferase beta
Synonym symbol(s) CCTB, CCT-beta, CTP
DNA
TYPE functioning gene
STRUCTURE 85.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CNK2 Xp22.13 similar to H326 FLJ34960 Xp22.13 hypothetical protein FLJ34960 SMPX Xp22.1 small muscle protein, X-linked MBTPS2 Xp22.1-p22.2 membrane-bound transcription factor protease, site 2 SMS Xp22.1 spermine synthase PHEX Xp22.2-p22.1 phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) FLJ25735 Xp22.13 hypothetical protein FLJ25735 LOC389841 X LOC389841 DDX53 Xp22 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 MGC45134 Xp22.13 hypothetical protein MGC45134 LOC392432 X similar to hypothetical protein MGC35083 FLJ30296 Xp22.13 hypothetical protein FLJ30296 PRDX4 Xp22.12-p21.3 peroxiredoxin 4 ACATE2 Xp22.13 likely ortholog of mouse acyl-Coenzyme A thioesterase 2, mitochondrial SAT Xp22.1 spermidine/spermine N1-acetyltransferase MGC4825 Xp22.13 hypothetical protein MGC4825 LOC317771 Xp22.1 ribosomal protein L9 pseudogene FLJ25444 Xp22.13 hypothetical protein FLJ25444 KIAA1677 Xp22.1-p21 KIAA1677 EIF2S3 Xp22.2-p22.1 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa ZFX Xp22.13-p22.12 zinc finger protein, X-linked LOC347438 Xp22.13 similar to P38IP protein LOC170067 Xp22.13 similar to transcription factor (p38 interacting protein) LOC286513 Xp22.13 similar to 40S ribosomal protein S26 PDK3 Xp22,12 pyruvate dehydrogenase kinase, isoenzyme 3 PCYT1B Xp22.12 phosphate cytidylyltransferase 1, choline, beta isoform POLA Xp22.12 polymerase (DNA directed), alpha ARX Xp22.12 aristaless related homeobox LOC139957 Xp22.12 similar to platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit (30kD); Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit LOC220895 Xp22.12 similar to methyltransferase-like protein 1 isoform a; D1075-like gene product LOC389842 X similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) MGC33889 Xp22.12 hypothetical protein MGC33889 LOC392433 X similar to melanoma antigen, family B, 6 MAGEB6 Xp22.11 similar to melanoma antigen, family B, 6 LOC347541 Xp22.12 similar to melanoma antigen 2 VENTX2P1 Xp22.12 VENT-like homeobox 2 pseudogene 1 LOC347543 Xp22.11 similar to 60S ribosomal protein L7 HMGA1L1 Xp22 high mobility group AT-hook 1-like 1 LOC139420 Xp22.11 similar to KIAA1387 protein RDXP2 Xp22.12 radixin pseudogene 2 FLJ32742 Xp22.11 hypothetical protein FLJ32742 LOC347442 Xp22.11 similar to H326 FLJ32965 Xp22.11 hypothetical protein FLJ32965 LOC392434 X similar to melanoma antigen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1317 35 330 - Karim
- - 1566 42 369 - Karim
- - - - - most highly expressed in brain and reproductive tissues, but not expressed in embryonic brain tissues Karim
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemovary   
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in placenta, fetal tissues
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • catalytic domain related to PCYT1A
  • three amphipatic helical repeats
  • three phosphorylation sites
  • a short C terminal tail
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing an unique role in the regulation of phosphatidyl choline biosynthesis in specific tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phosphatidyl choline
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS